1wwl

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[[Image:1wwl.png|left|200px]]
 
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{{STRUCTURE_1wwl| PDB=1wwl | SCENE= }}
{{STRUCTURE_1wwl| PDB=1wwl | SCENE= }}
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===Crystal structure of CD14===
===Crystal structure of CD14===
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{{ABSTRACT_PUBMED_15644310}}
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==Function==
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[[http://www.uniprot.org/uniprot/CD14_MOUSE CD14_MOUSE]] Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).
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(as it appears on PubMed at http://www.pubmed.gov), where 15644310 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15644310}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015644310</ref><references group="xtra"/>
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<ref group="xtra">PMID:015644310</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Jin, M S.]]
[[Category: Jin, M S.]]

Revision as of 08:19, 23 April 2014

Template:STRUCTURE 1wwl

Contents

Crystal structure of CD14

Template:ABSTRACT PUBMED 15644310

Function

[CD14_MOUSE] Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity).

About this Structure

1wwl is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, Lee H, Lee JO. Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem. 2005 Mar 25;280(12):11347-51. Epub 2005 Jan 10. PMID:15644310 doi:10.1074/jbc.M414607200

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OCA

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