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2i99

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[[Image:2i99.png|left|200px]]
 
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{{STRUCTURE_2i99| PDB=2i99 | SCENE= }}
{{STRUCTURE_2i99| PDB=2i99 | SCENE= }}
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===Crystal structure of human Mu_crystallin at 2.6 Angstrom===
===Crystal structure of human Mu_crystallin at 2.6 Angstrom===
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{{ABSTRACT_PUBMED_17242435}}
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==Function==
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[[http://www.uniprot.org/uniprot/CRYM_HUMAN CRYM_HUMAN]] Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.<ref>PMID:21332720</ref>
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{{ABSTRACT_PUBMED_17242435}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:017242435</ref><references group="xtra"/>
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<ref group="xtra">PMID:017242435</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Cheng, Z.]]
[[Category: Cheng, Z.]]

Revision as of 08:19, 23 April 2014

Template:STRUCTURE 2i99

Contents

Crystal structure of human Mu_crystallin at 2.6 Angstrom

Template:ABSTRACT PUBMED 17242435

Function

[CRYM_HUMAN] Specifically catalyzes the reduction of imine bonds in brain substrates that may include cystathionine ketimine (CysK) and lanthionine ketimine (LK). Binds thyroid hormone which is a strong reversible inhibitor. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.[1]

About this Structure

2i99 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Cheng Z, Sun L, He J, Gong W. Crystal structure of human micro-crystallin complexed with NADPH. Protein Sci. 2007 Feb;16(2):329-35. PMID:17242435 doi:http://dx.doi.org/16/2/329
  1. ↑ Hallen A, Cooper AJ, Jamie JF, Haynes PA, Willows RD. Mammalian forebrain ketimine reductase identified as mu-crystallin; potential regulation by thyroid hormones. J Neurochem. 2011 Aug;118(3):379-87. doi: 10.1111/j.1471-4159.2011.07220.x. Epub , 2011 Mar 15. PMID:21332720 doi:http://dx.doi.org/10.1111/j.1471-4159.2011.07220.x

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OCA

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