We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
2atb
From Proteopedia
(Difference between revisions)
m (Protected "2atb" [edit=sysop:move=sysop]) |
Revision as of 08:20, 23 April 2014
Triple mutant 8D9D10V of scorpion toxin LQH-alpha-IT
Function
[SCXA_LEIQH] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice.
About this Structure
2atb is a 2 chain structure with sequence from Leiurus quinquestriatus. Full crystallographic information is available from OCA.
Categories: Leiurus quinquestriatus | Frolow, F. | Gurevitz, M. | Kahn, R. | Karbat, I. | Alpha toxin | Muation | Scorpion | Toxin
