1u9q

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m (Protected "1u9q" [edit=sysop:move=sysop])
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[[Image:1u9q.png|left|200px]]
 
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{{STRUCTURE_1u9q| PDB=1u9q | SCENE= }}
{{STRUCTURE_1u9q| PDB=1u9q | SCENE= }}
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===Crystal structure of cruzain bound to an alpha-ketoester===
===Crystal structure of cruzain bound to an alpha-ketoester===
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{{ABSTRACT_PUBMED_15727867}}
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==Function==
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[[http://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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(as it appears on PubMed at http://www.pubmed.gov), where 15727867 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15727867}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:015727867</ref><references group="xtra"/>
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<ref group="xtra">PMID:015727867</ref><references group="xtra"/><references/>
[[Category: Cruzipain]]
[[Category: Cruzipain]]
[[Category: Trypanosoma cruzi]]
[[Category: Trypanosoma cruzi]]

Revision as of 08:25, 23 April 2014

Template:STRUCTURE 1u9q

Contents

Crystal structure of cruzain bound to an alpha-ketoester

Template:ABSTRACT PUBMED 15727867

Function

[CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.

About this Structure

1u9q is a 1 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.

Reference

  • Choe Y, Brinen LS, Price MS, Engel JC, Lange M, Grisostomi C, Weston SG, Pallai PV, Cheng H, Hardy LW, Hartsough DS, McMakin M, Tilton RF, Baldino CM, Craik CS. Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease. Bioorg Med Chem. 2005 Mar 15;13(6):2141-56. PMID:15727867 doi:10.1016/j.bmc.2004.12.053

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OCA

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