2f8f
From Proteopedia
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{{STRUCTURE_2f8f| PDB=2f8f | SCENE= }} | {{STRUCTURE_2f8f| PDB=2f8f | SCENE= }} | ||
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===Crystal structure of the Y10F mutant of the gluathione s-transferase from schistosoma haematobium=== | ===Crystal structure of the Y10F mutant of the gluathione s-transferase from schistosoma haematobium=== | ||
| + | {{ABSTRACT_PUBMED_16777141}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/GST28_SCHBO GST28_SCHBO]] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. | |
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==About this Structure== | ==About this Structure== | ||
[[2f8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8F OCA]. | [[2f8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Schistosoma_haematobium Schistosoma haematobium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8F OCA]. | ||
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| + | ==See Also== | ||
| + | *[[Glutathione S-transferase|Glutathione S-transferase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:016777141</ref><references group="xtra"/> | + | <ref group="xtra">PMID:016777141</ref><references group="xtra"/><references/> |
[[Category: Glutathione transferase]] | [[Category: Glutathione transferase]] | ||
[[Category: Schistosoma haematobium]] | [[Category: Schistosoma haematobium]] | ||
Revision as of 08:29, 23 April 2014
Contents |
Crystal structure of the Y10F mutant of the gluathione s-transferase from schistosoma haematobium
Template:ABSTRACT PUBMED 16777141
Function
[GST28_SCHBO] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut.
About this Structure
2f8f is a 2 chain structure with sequence from Schistosoma haematobium. Full crystallographic information is available from OCA.
See Also
Reference
- Baiocco P, Gourlay LJ, Angelucci F, Fontaine J, Herve M, Miele AE, Trottein F, Brunori M, Bellelli A. Probing the mechanism of GSH activation in Schistosoma haematobium glutathione-S-transferase by site-directed mutagenesis and X-ray crystallography. J Mol Biol. 2006 Jul 14;360(3):678-89. Epub 2006 Jun 2. PMID:16777141 doi:10.1016/j.jmb.2006.05.040
