This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2e68
From Proteopedia
m (Protected "2e68" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:2e68.png|left|200px]] | ||
| - | |||
| - | <!-- | ||
| - | The line below this paragraph, containing "STRUCTURE_2e68", creates the "Structure Box" on the page. | ||
| - | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| - | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| - | or leave the SCENE parameter empty for the default display. | ||
| - | --> | ||
{{STRUCTURE_2e68| PDB=2e68 | SCENE= }} | {{STRUCTURE_2e68| PDB=2e68 | SCENE= }} | ||
| - | |||
===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate=== | ===Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate=== | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/Q4D3W2_TRYCR Q4D3W2_TRYCR]] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro. | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
==About this Structure== | ==About this Structure== | ||
[[2e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E68 OCA]. | [[2e68]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E68 OCA]. | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dihydroorotate dehydrogenase|Dihydroorotate dehydrogenase]] | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:018808149</ref><references group="xtra"/> | + | <ref group="xtra">PMID:018808149</ref><references group="xtra"/><references/> |
[[Category: Dihydroorotate oxidase]] | [[Category: Dihydroorotate oxidase]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
Revision as of 08:36, 23 April 2014
Contents |
Crystal structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with dihydroorotate
Function
[Q4D3W2_TRYCR] Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor. Molecular oxygen can replace fumarate in vitro.
About this Structure
2e68 is a 2 chain structure with sequence from Trypanosoma cruzi. Full crystallographic information is available from OCA.
See Also
Reference
- Inaoka DK, Sakamoto K, Shimizu H, Shiba T, Kurisu G, Nara T, Aoki T, Kita K, Harada S. Structures of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with substrates and products: atomic resolution insights into mechanisms of dihydroorotate oxidation and fumarate reduction. Biochemistry. 2008 Oct 14;47(41):10881-91. Epub 2008 Sep 23. PMID:18808149 doi:10.1021/bi800413r
Categories: Dihydroorotate oxidase | Trypanosoma cruzi | Aoki, T. | Harada, S. | Inaoka, D K. | Kita, K. | Kurisu, G. | Nara, T. | Sakamoto, K. | Shiba, T. | Shimizu, H. | Chagas disease | Dihydroorotate dehydrogenase | Energy metabolism | Flavoprotein | Fumarate reductase | Oxidoreductase | Pyrimidine biosynthesis | Redox homeostasis
