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1seg

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Revision as of 08:39, 23 April 2014

Template:STRUCTURE 1seg

Contents

Crystal structure of a toxin chimera between Lqh-alpha-IT from the scorpion Leiurus quinquestriatus hebraeus and AAH2 from Androctonus australis hector

Template:ABSTRACT PUBMED 15133045

Function

[SCX2_ANDAU] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against mammals.

About this Structure

1seg is a 1 chain structure with sequence from Androctonus australis hector. Full crystallographic information is available from OCA.

Reference

  • Karbat I, Frolow F, Froy O, Gilles N, Cohen L, Turkov M, Gordon D, Gurevitz M. Molecular basis of the high insecticidal potency of scorpion alpha-toxins. J Biol Chem. 2004 Jul 23;279(30):31679-86. Epub 2004 May 8. PMID:15133045 doi:10.1074/jbc.M402048200

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OCA

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