2c91

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[[Image:2c91.png|left|200px]]
 
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{{STRUCTURE_2c91| PDB=2c91 | SCENE= }}
{{STRUCTURE_2c91| PDB=2c91 | SCENE= }}
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===MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5===
===MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5===
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{{ABSTRACT_PUBMED_16460003}}
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==Function==
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[[http://www.uniprot.org/uniprot/ARK72_MOUSE ARK72_MOUSE]] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).<ref>PMID:16460003</ref>
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{{ABSTRACT_PUBMED_16460003}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:016460003</ref><ref group="xtra">PMID:012123834</ref><references group="xtra"/>
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<ref group="xtra">PMID:016460003</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Ellis, E M.]]
[[Category: Ellis, E M.]]

Revision as of 08:40, 23 April 2014

Template:STRUCTURE 2c91

Contents

MOUSE SUCCINIC SEMIALDEHYDE REDUCTASE, AKR7A5

Template:ABSTRACT PUBMED 16460003

Function

[ARK72_MOUSE] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity).[1]

About this Structure

2c91 is a 10 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  • Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k
  1. ↑ Zhu X, Lapthorn AJ, Ellis EM. Crystal structure of mouse succinic semialdehyde reductase AKR7A5: structural basis for substrate specificity. Biochemistry. 2006 Feb 14;45(6):1562-70. PMID:16460003 doi:10.1021/bi051610k

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OCA

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