1tjx
From Proteopedia
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{{STRUCTURE_1tjx| PDB=1tjx | SCENE= }} | {{STRUCTURE_1tjx| PDB=1tjx | SCENE= }} | ||
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===Crystallographic Identification of Ca2+ Coordination Sites in Synaptotagmin I C2B Domain=== | ===Crystallographic Identification of Ca2+ Coordination Sites in Synaptotagmin I C2B Domain=== | ||
| + | {{ABSTRACT_PUBMED_15340165}} | ||
| - | + | ==Function== | |
| - | + | [[http://www.uniprot.org/uniprot/SYT1_RAT SYT1_RAT]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. | |
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID:015340165</ref><references group="xtra"/> | + | <ref group="xtra">PMID:015340165</ref><references group="xtra"/><references/> |
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Cheng, Y.]] | [[Category: Cheng, Y.]] | ||
Revision as of 08:48, 23 April 2014
Contents |
Crystallographic Identification of Ca2+ Coordination Sites in Synaptotagmin I C2B Domain
Template:ABSTRACT PUBMED 15340165
Function
[SYT1_RAT] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2.
About this Structure
1tjx is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Cheng Y, Sequeira SM, Malinina L, Tereshko V, Sollner TH, Patel DJ. Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain. Protein Sci. 2004 Oct;13(10):2665-72. Epub 2004 Aug 31. PMID:15340165 doi:10.1110/ps.04832604
