1uzn

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[[Image:1uzn.png|left|200px]]
 
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{{STRUCTURE_1uzn| PDB=1uzn | SCENE= }}
{{STRUCTURE_1uzn| PDB=1uzn | SCENE= }}
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===MABA FROM MYCOBACTERIUM TUBERCULOSIS===
===MABA FROM MYCOBACTERIUM TUBERCULOSIS===
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{{ABSTRACT_PUBMED_12079383}}
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==Function==
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[[http://www.uniprot.org/uniprot/FABG_MYCTU FABG_MYCTU]] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. MabA preferentially metabolizes long-chain substrates (C8-C20) and has a poor affinity for the C4 substrate.<ref>PMID:9802011</ref> <ref>PMID:11932442</ref> <ref>PMID:19685079</ref>
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{{ABSTRACT_PUBMED_12079383}}
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==About this Structure==
==About this Structure==
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==Reference==
==Reference==
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<ref group="xtra">PMID:012079383</ref><references group="xtra"/>
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<ref group="xtra">PMID:012079383</ref><references group="xtra"/><references/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Cohen-Gonsaud, M.]]
[[Category: Cohen-Gonsaud, M.]]

Revision as of 08:50, 23 April 2014

Template:STRUCTURE 1uzn

Contents

MABA FROM MYCOBACTERIUM TUBERCULOSIS

Template:ABSTRACT PUBMED 12079383

Function

[FABG_MYCTU] Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. MabA preferentially metabolizes long-chain substrates (C8-C20) and has a poor affinity for the C4 substrate.[1] [2] [3]

About this Structure

1uzn is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

  • Cohen-Gonsaud M, Ducasse S, Hoh F, Zerbib D, Labesse G, Quemard A. Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis. J Mol Biol. 2002 Jul 5;320(2):249-61. PMID:12079383 doi:10.1016/S0022-2836(02)00463-1
  1. ↑ Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR Jr. The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance. Microbiology. 1998 Oct;144 ( Pt 10):2697-704. PMID:9802011
  2. ↑ Marrakchi H, Ducasse S, Labesse G, Montrozier H, Margeat E, Emorine L, Charpentier X, Daffe M, Quemard A. MabA (FabG1), a Mycobacterium tuberculosis protein involved in the long-chain fatty acid elongation system FAS-II. Microbiology. 2002 Apr;148(Pt 4):951-60. PMID:11932442
  3. ↑ Gurvitz A. The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2. Mol Genet Genomics. 2009 Oct;282(4):407-16. Epub 2009 Aug 14. PMID:19685079 doi:http://dx.doi.org/10.1007/s00438-009-0474-2

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OCA

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