2byc

From Proteopedia

Revision as of 14:47, 30 October 2007

BLRB- A BLUF PROTEIN, DARK STATE STRUCTURE

Overview

Light is an essential environmental factor, and many species have evolved, the capability to respond to it. Blue light is perceived through three, flavin-containing photoreceptor families: cryptochromes, light-oxygen-voltage, and BLUF (sensor of blue light using flavin adenine, dinucleotide, FAD) domain proteins. BLUF domains are present in various, proteins from Bacteria and lower Eukarya. They are fully modular and can, relay signals to structurally and functionally diverse output units, most, of which are implicated in nucleotide metabolism. We present the high, resolution crystal structure of the dark resting state of BlrB, a short, BLUF domain-containing protein from Rhodobacter sphaeroides. The structure, reveals a previously uncharacterized FAD-binding fold. Along with other, lines ... [(full description)]

About this Structure

2BYC is a [Single protein] structure of sequence from [Rhodobacter sphaeroides] with FMN as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transduction., Jung A, Domratcheva T, Tarutina M, Wu Q, Ko WH, Shoeman RL, Gomelsky M, Gardner KH, Schlichting I, Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12350-5. Epub 2005 Aug 17. PMID:16107542

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