2qk5
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(New page: 200px<br /><applet load="2qk5" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qk5, resolution 2.200Å" /> '''Structure of BACE1 ...)
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Revision as of 07:34, 14 March 2008
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Structure of BACE1 bound to SCH626485
Overview
Based on lead compound 1 identified from the patent literature, we developed novel patentable BACE-1 inhibitors by introducing a cyclic amine scaffold. Extensive SAR studies on both pyrrolidines and piperidines ultimately led to inhibitor 2f, one of the most potent inhibitors synthesized to date.
About this Structure
2QK5 is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Memapsin 2, with EC number 3.4.23.46 Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Potent pyrrolidine- and piperidine-based BACE-1 inhibitors., Iserloh U, Wu Y, Cumming JN, Pan J, Wang LY, Stamford AW, Kennedy ME, Kuvelkar R, Chen X, Parker EM, Strickland C, Voigt J, Bioorg Med Chem Lett. 2008 Jan 1;18(1):414-7. Epub 2007 Nov 6. PMID:18023580
Page seeded by OCA on Fri Mar 14 09:34:37 2008
Categories: Homo sapiens | Memapsin 2 | Single protein | Iserloh, U. | Strickland, C O. | CS5 | Alternative splicing | Aspartyl protease | Bace1 | Glycoprotein | Hydrolase | Membrane | Protease | Transmembrane | Zymogen
