2m0q
From Proteopedia
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| - | ''' | + | ==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix== |
| - | + | <StructureSection load='2m0q' size='340' side='right' caption='[[2m0q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | [[2m0q]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0Q OCA]. <br> | |
| - | + | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | |
| - | + | == Disease == | |
| - | + | [[http://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Chen, L.]] | ||
| + | [[Category: Lai, C.]] | ||
| + | [[Category: Li, P.]] | ||
| + | [[Category: Tian, C.]] | ||
| + | [[Category: Wu, F.]] | ||
| + | [[Category: Zhang, L.]] | ||
| + | [[Category: Detergent micelle]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Transmembrane helix]] | ||
Revision as of 07:53, 30 April 2014
Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix
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