4py0
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of P2Y12 receptor in complex with 2MeSATP== |
| - | + | <StructureSection load='4py0' size='340' side='right' caption='[[4py0]], [[Resolution|resolution]] 3.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | [[4py0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PY0 OCA]. <br> | |
| - | + | <b>Related:</b> [[4ntj|4ntj]], [[4pxz|4pxz]]<br> | |
| - | + | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | |
| - | + | == Disease == | |
| + | [[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/P2Y12_HUMAN P2Y12_HUMAN]] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cherezov, V.]] | ||
| + | [[Category: GPCR, GPCR Network.]] | ||
| + | [[Category: Gao, Z G.]] | ||
| + | [[Category: Han, G W.]] | ||
| + | [[Category: Jacobson, K A.]] | ||
| + | [[Category: Jiang, H.]] | ||
| + | [[Category: Katritch, V.]] | ||
| + | [[Category: Li, T.]] | ||
| + | [[Category: Ma, L.]] | ||
| + | [[Category: Muller, C E.]] | ||
| + | [[Category: Paoletta, S.]] | ||
| + | [[Category: Stevens, R C.]] | ||
| + | [[Category: Wu, B.]] | ||
| + | [[Category: Yang, H.]] | ||
| + | [[Category: Zhang, D.]] | ||
| + | [[Category: Zhang, J.]] | ||
| + | [[Category: Zhang, K.]] | ||
| + | [[Category: Zhang, W.]] | ||
| + | [[Category: Zhao, Q.]] | ||
| + | [[Category: Gpcr]] | ||
| + | [[Category: Gpcr network]] | ||
| + | [[Category: Membrane]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Partial agonist-bound]] | ||
| + | [[Category: Platelet activation]] | ||
| + | [[Category: Psi-biology]] | ||
| + | [[Category: Purinergic receptor p2y12]] | ||
| + | [[Category: Signaling membrane protein]] | ||
| + | [[Category: Signaling protein-nucleotide complex]] | ||
| + | [[Category: Structural genomic]] | ||
Revision as of 08:10, 30 April 2014
Crystal structure of P2Y12 receptor in complex with 2MeSATP
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Categories: Cherezov, V. | GPCR, GPCR Network. | Gao, Z G. | Han, G W. | Jacobson, K A. | Jiang, H. | Katritch, V. | Li, T. | Ma, L. | Muller, C E. | Paoletta, S. | Stevens, R C. | Wu, B. | Yang, H. | Zhang, D. | Zhang, J. | Zhang, K. | Zhang, W. | Zhao, Q. | Gpcr | Gpcr network | Membrane | Membrane protein | Partial agonist-bound | Platelet activation | Psi-biology | Purinergic receptor p2y12 | Signaling membrane protein | Signaling protein-nucleotide complex | Structural genomic
