2l97

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[[Image:2l97.jpg|left|200px]]
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==Solution structure of HtrA PDZ domain from Streptococcus pneumoniae==
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<StructureSection load='2l97' size='340' side='right' caption='[[2l97]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2l97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L97 OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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High-temperature requirement A (HtrA), a highly conserved family of serine protease, plays crucial roles in protein quality control in prokaryotes and eukaryotes. The HtrA protein contains a C-terminal PDZ domain that mediates the proteolytic activity. Here we reported the solution structure of the HtrA PDZ domain from Streptococcus pneumoniae by NMR spectroscopy. Our results showed that the structure of HtrA PDZ domain, which contains three alpha-helices and five beta-strands, illustrates conservation within the canonical PDZ domains. In addition, we demonstrated the interactions between S. pneumoniae HtrA PDZ domain and peptides with the motif XXX-YYF-COOH by surface plasmon resonance. Besides, we identified the ligand binding surface and the critical residues responsible for ligand binding of HtrA PDZ domain by chemical shift perturbation and site-directed mutagenesis.
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Solution structure of HtrA PDZ domain from Streptococcus pneumoniae and its interaction with YYF-COOH containing peptides.,Fan K, Zhang J, Zhang X, Tu X J Struct Biol. 2011 Oct;176(1):16-23. Epub 2011 Jul 2. PMID:21757011<ref>PMID:21757011</ref>
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The line below this paragraph, containing "STRUCTURE_2l97", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_2l97| PDB=2l97 | SCENE= }}
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===Solution structure of HtrA PDZ domain from Streptococcus pneumoniae===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21757011}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21757011 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21757011}}
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==About this Structure==
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[[2l97]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L97 OCA].
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==Reference==
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<ref group="xtra">PMID:021757011</ref><ref group="xtra">PMID:020437142</ref><references group="xtra"/>
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[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
[[Category: Fan, K.]]
[[Category: Fan, K.]]

Revision as of 08:20, 30 April 2014

Solution structure of HtrA PDZ domain from Streptococcus pneumoniae

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