2l9x

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[[Image:2l9x.png|left|200px]]
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==Trn- peptide of the two-component bacteriocin Thuricin CD==
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<StructureSection load='2l9x' size='340' side='right' caption='[[2l9x]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2l9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_cereus_95/8201 Bacillus cereus 95/8201]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9X OCA]. <br>
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<b>Related:</b> [[2la0|2la0]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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Thuricin CD is an antimicrobial factor that consists of two peptides, Trn-alpha and Trn-beta, that exhibit synergistic activity against drug resistant strains of Clostridium difficile. Trn-alpha and Trn-beta each possess three sulfur to alpha-carbon thioether bridges for which the stereochemistry is unknown. This report presents the three-dimensional solution structures of Trn-alpha and Trn-beta. Structure calculations were performed for the eight possible stereoisomers of each peptide based on the same NMR data. The structure of the stereoisomer that best fit the experimental data was chosen as the representative structure for each peptide. It was determined that Trn-alpha has L-stereochemistry at Ser21 (alpha-R), L-stereochemistry at Thr25 (alpha-R), and D-stereochemistry at Thr28 (alpha-S) (an LLD isomer). Trn-beta was also found to be the LLD isomer, with L-stereochemistry at Thr21 (alpha-R), L-stereochemistry at Ala25 (alpha-R), and D-stereochemistry at Tyr28 (alpha-S).
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The 3D structure of thuricin CD, a two-component bacteriocin with cysteine sulfur to alpha-carbon cross-links.,Sit CS, McKay RT, Hill C, Ross RP, Vederas JC J Am Chem Soc. 2011 May 25;133(20):7680-3. Epub 2011 Apr 28. PMID:21526839<ref>PMID:21526839</ref>
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The line below this paragraph, containing "STRUCTURE_2l9x", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2l9x| PDB=2l9x | SCENE= }}
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===Trn- peptide of the two-component bacteriocin Thuricin CD===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_21526839}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21526839 is the PubMed ID number.
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[[Category: Bacillus cereus 95/8201]]
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{{ABSTRACT_PUBMED_21526839}}
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==About this Structure==
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[[2l9x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacteria Bacteria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L9X OCA].
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==Reference==
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<ref group="xtra">PMID:021526839</ref><references group="xtra"/>
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[[Category: Bacteria]]
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[[Category: Hill, C.]]
[[Category: Hill, C.]]
[[Category: Mckay, R T.]]
[[Category: Mckay, R T.]]

Revision as of 08:21, 30 April 2014

Trn- peptide of the two-component bacteriocin Thuricin CD

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