2la8

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[[Image:2la8.png|left|200px]]
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==Solution structure of INAD PDZ5 complexed with Kon-tiki peptide==
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<StructureSection load='2la8' size='340' side='right' caption='[[2la8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2la8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA8 OCA]. <br>
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<b>Related:</b> [[3r0h|3r0h]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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INAD is a scaffolding protein that regulates signaling in Drosophila photoreceptors. One of its PDZ domains, PDZ5, cycles between reduced and oxidized forms in response to light, but it is unclear how light affects its redox potential. Through biochemical and structural studies, we show that the redox potential of PDZ5 is allosterically regulated by its interaction with another INAD domain, PDZ4. Whereas isolated PDZ5 is stable in the oxidized state, formation of a PDZ45 "supramodule" locks PDZ5 in the reduced state by raising the redox potential of its Cys606/Cys645 disulfide bond by approximately 330 mV. Acidification, potentially mediated via light and PLCbeta-mediated hydrolysis of PIP(2), disrupts the interaction between PDZ4 and PDZ5, leading to PDZ5 oxidation and dissociation from the TRP Ca(2+) channel, a key component of fly visual signaling. These results show that scaffolding proteins can actively modulate the intrinsic redox potentials of their disulfide bonds to exert regulatory roles in signaling.
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The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye.,Liu W, Wen W, Wei Z, Yu J, Ye F, Liu CH, Hardie RC, Zhang M Cell. 2011 Jun 24;145(7):1088-101. PMID:21703451<ref>PMID:21703451</ref>
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The line below this paragraph, containing "STRUCTURE_2la8", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2la8| PDB=2la8 | SCENE= }}
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===Solution structure of INAD PDZ5 complexed with Kon-tiki peptide===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_21703451}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21703451 is the PubMed ID number.
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[[Category: Drome]]
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{{ABSTRACT_PUBMED_21703451}}
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==About this Structure==
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[[2la8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster,_synthetic,_synthetic Drosophila melanogaster, synthetic, synthetic]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LA8 OCA].
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==Reference==
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<ref group="xtra">PMID:021703451</ref><references group="xtra"/>
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[[Category: Drosophila melanogaster, synthetic, synthetic]]
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[[Category: Wen, W.]]
[[Category: Wen, W.]]
[[Category: Zhang, M.]]
[[Category: Zhang, M.]]
[[Category: Peptide binding protein]]
[[Category: Peptide binding protein]]

Revision as of 08:22, 30 April 2014

Solution structure of INAD PDZ5 complexed with Kon-tiki peptide

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