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2l8i

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[[Image:2l8i.jpg|left|200px]]
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==A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex==
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<StructureSection load='2l8i' size='340' side='right' caption='[[2l8i]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''>
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== Structural highlights ==
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[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen. The results explain the surprising biocompatibility of triazole-linked DNA.
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Structure and Dynamics of Triazole-Linked DNA: Biocompatibility Explained.,Dallmann A, El-Sagheer AH, Dehmel L, Mugge C, Griesinger C, Ernsting NP, Brown T Chemistry. 2011 Dec 23;17(52):14714-7. doi: 10.1002/chem.201102979. Epub, 2011 Nov 30. PMID:22131102<ref>PMID:22131102</ref>
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The line below this paragraph, containing "STRUCTURE_2l8i", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2l8i| PDB=2l8i | SCENE= }}
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===A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_22131102}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22131102 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22131102}}
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==About this Structure==
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[[2l8i]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L8I OCA].
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==Reference==
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<ref group="xtra">PMID:022131102</ref><references group="xtra"/>
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[[Category: Brown, T.]]
[[Category: Brown, T.]]
[[Category: Dehmel, L.]]
[[Category: Dehmel, L.]]

Revision as of 08:24, 30 April 2014

A biocompatible backbone modification? - Structure and dynamics of a triazole-linked DNA duplex

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