2l66

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[[Image:2l66.jpg|left|200px]]
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==The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.==
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<StructureSection load='2l66' size='340' side='right' caption='[[2l66]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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== Structural highlights ==
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[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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Organisms growing at elevated temperatures face the challenge of maintaining the integrity of their genetic materials. Archaea possess unique chromatin proteins for gene organization and information processing. We present the solution structure of Sso7c4 from Sulfolobus solfataricus, which has a homodimeric DNA-binding fold forming a swapped beta-loop-beta 'Tai-Chi' topology. The fold is reminiscent of the N-terminal DNA-binding domain of AbrB and MazE. In addition, several amide resonances in the heteronuclear single quantum coherence spectra of Sso7c4 are shifted and broadened with the addition of small amounts of duplex DNA oligomers. The locations of the corresponding amides in the Sso7c4 structure define its DNA-interacting surface. NMR spectra of DNA titrated with the protein further indicated that Sso7c4 interacts with DNA in the major groove. Taken together, a plausible model for the Sso7c4-DNA complex is presented, in which the DNA double helix is curved around the protein dimer.
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The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.,Hsu CH, Wang AH Nucleic Acids Res. 2011 Aug;39(15):6764-74. Epub 2011 May 5. PMID:21546550<ref>PMID:21546550</ref>
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The line below this paragraph, containing "STRUCTURE_2l66", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_2l66| PDB=2l66 | SCENE= }}
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===The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21546550}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21546550 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21546550}}
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==About this Structure==
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[[2l66]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sulfolobus_solfataricus Sulfolobus solfataricus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L66 OCA].
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==Reference==
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<ref group="xtra">PMID:021546550</ref><references group="xtra"/>
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[[Category: Sulfolobus solfataricus]]
[[Category: Sulfolobus solfataricus]]
[[Category: Hsu, C H.]]
[[Category: Hsu, C H.]]

Revision as of 08:25, 30 April 2014

The DNA-recognition fold of Sso7c4 suggests a new member of SpoVT-AbrB superfamily from archaea.

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