2lgq

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[[Image:2lgq.png|left|200px]]
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==Human C30S/C59S-Cox17 mutant==
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<StructureSection load='2lgq' size='340' side='right' caption='[[2lgq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2lgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGQ OCA]. <br>
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<b>Related:</b> [[2rn9|2rn9]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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Human Cox17 is the mitochondrial copper chaperone responsible for supplying copper ions, through the assistance of Sco1, Sco2, and Cox11, to cytochrome c oxidase, the terminal enzyme of the mitochondrial energy-transducing respiratory chain. It consists of a coiled coil-helix-coiled coil-helix domain stabilized by two disulfide bonds and binds one copper(I) ion through a Cys-Cys motif. Here, the structures and the backbone mobilities of two Cox17 mutated forms with only one interhelical disulfide bond have been analyzed. It appears that the inner disulfide bond (formed by Cys-36 and Cys-45) stabilizes interhelical hydrophobic interactions, providing a structure with essentially the same structural dynamic properties of the mature Cox17 state. On the contrary, the external disulfide bond (formed by Cys-26 and Cys-55) generates a conformationally flexible alpha-helical protein, indicating that it is not able to stabilize interhelical packing contacts, but is important for structurally organizing the copper-binding site region.
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Functional role of two interhelical disulfide bonds in human cox17 protein from a structural perspective.,Banci L, Bertini I, Cefaro C, Ciofi-Baffoni S, Gallo A J Biol Chem. 2011 Sep 30;286(39):34382-90. Epub 2011 Aug 4. PMID:21816817<ref>PMID:21816817</ref>
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The line below this paragraph, containing "STRUCTURE_2lgq", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2lgq| PDB=2lgq | SCENE= }}
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===Human C30S/C59S-Cox17 mutant===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21816817}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21816817 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21816817}}
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==About this Structure==
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[[2lgq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LGQ OCA].
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==Reference==
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<ref group="xtra">PMID:021816817</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bertini, I.]]
[[Category: Bertini, I.]]

Revision as of 08:25, 30 April 2014

Human C30S/C59S-Cox17 mutant

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