2kwl

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[[Image:2kwl.png|left|200px]]
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==Solution Structure of acyl carrier protein from Borrelia burgdorferi==
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<StructureSection load='2kwl' size='340' side='right' caption='[[2kwl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2kwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KWL OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kw/2kwl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
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Nearly complete resonance assignment and the high-resolution NMR structure of the acyl-carrier protein from Borrelia burgdorferi, a target of the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure-determination pipeline, are reported. This protein was chosen as a potential target for drug-discovery efforts because of its involvement in fatty-acid biosynthesis, an essential metabolic pathway, in bacteria. It was possible to assign &gt;98% of backbone resonances and &gt;92% of side-chain resonances using multidimensional NMR spectroscopy. The NMR structure was determined to a backbone r.m.s.d. of 0.4 A and contained four alpha-helices and two 3(10)-helices. A structure-homology search revealed that this protein is highly similar to the acyl-carrier protein from Aquifex aeolicus.
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<!--
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NMR structure of an acyl-carrier protein from Borrelia burgdorferi.,Barnwal RP, Van Voorhis WC, Varani G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1137-40. Epub 2011 Aug 13. PMID:21904063<ref>PMID:21904063</ref>
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The line below this paragraph, containing "STRUCTURE_2kwl", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2kwl| PDB=2kwl | SCENE= }}
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===Solution Structure of acyl carrier protein from Borrelia burgdorferi===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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<!--
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_21904063}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 21904063 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_21904063}}
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==About this Structure==
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[[2kwl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Borrelia_burgdorferi Borrelia burgdorferi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KWL OCA].
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==Reference==
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<ref group="xtra">PMID:021904063</ref><references group="xtra"/>
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[[Category: Borrelia burgdorferi]]
[[Category: Borrelia burgdorferi]]
[[Category: Barnwal, R.]]
[[Category: Barnwal, R.]]

Revision as of 08:27, 30 April 2014

Solution Structure of acyl carrier protein from Borrelia burgdorferi

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