2jpo

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[[Image:2jpo.png|left|200px]]
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==NMR structure of Antheraea polyphemus pheromone-binding protein 1 at pH 4.5==
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<StructureSection load='2jpo' size='340' side='right' caption='[[2jpo]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2jpo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Antheraea_polyphemus Antheraea polyphemus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPO OCA]. <br>
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<b>Related:</b> [[1gm0|1gm0]], [[1two|1two]], [[1ls8|1ls8]], [[1qwv|1qwv]], [[1xfr|1xfr]], [[1dqe|1dqe]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jp/2jpo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
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The NMR structure of the Antheraea polyphemus pheromone-binding protein 1 at pH 4.5, ApolPBP1A, was determined at 20 degrees C. The structure consists of six alpha-helices, which are arranged in a globular fold that encapsulates a central helix alpha7 formed by the C-terminal polypeptide segment 131-142. The 3D arrangement of these helices is anchored by the three disulfide bonds 19-54, 50-108 and 97-117, which were identified by NMR. Superposition of the ApolPBP1A structure with the structure of the homologous pheromone-binding protein of Bombyx mori at pH 4.5, BmorPBPA, yielded an rmsd of 1.7 A calculated for the backbone heavy-atoms N, Calpha and C' of residues 10-142. In contrast, the present ApolPBP1A structure is different from a recently proposed molecular model for a low-pH form of ApolPBP1 that does not contain the central helix alpha7. ApolPBP1 exhibits a pH-dependent transition between two different globular conformations in slow exchange on the NMR chemical shift timescale similar to BmorPBP, suggesting that the two proteins use the same mechanism of ligand binding and ejection. The extensive sequence homology observed for pheromone-binding proteins from moth species further implies that the previously proposed mechanism of ligand ejection involving the insertion of a C-terminal helix into the pheromone-binding site is a general feature of pheromone signaling in moths.
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Structural basis of ligand binding and release in insect pheromone-binding proteins: NMR structure of Antheraea polyphemus PBP1 at pH 4.5.,Damberger FF, Ishida Y, Leal WS, Wuthrich K J Mol Biol. 2007 Nov 2;373(4):811-9. Epub 2007 Aug 17. PMID:17884092<ref>PMID:17884092</ref>
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The line below this paragraph, containing "STRUCTURE_2jpo", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2jpo| PDB=2jpo | SCENE= }}
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===NMR structure of Antheraea polyphemus pheromone-binding protein 1 at pH 4.5===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_17884092}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 17884092 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_17884092}}
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==About this Structure==
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[[2jpo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Antheraea_polyphemus Antheraea polyphemus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JPO OCA].
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==Reference==
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<ref group="xtra">PMID:017884092</ref><ref group="xtra">PMID:012522306</ref><ref group="xtra">PMID:012051947</ref><ref group="xtra">PMID:009367762</ref><ref group="xtra">PMID:008914272</ref><references group="xtra"/>
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[[Category: Antheraea polyphemus]]
[[Category: Antheraea polyphemus]]
[[Category: Damberger, F F.]]
[[Category: Damberger, F F.]]

Revision as of 08:28, 30 April 2014

NMR structure of Antheraea polyphemus pheromone-binding protein 1 at pH 4.5

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