2ler

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2ler.png|left|200px]]
+
==Conotoxin pc16a==
 +
<StructureSection load='2ler' size='340' side='right' caption='[[2ler]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 +
== Structural highlights ==
 +
[[2ler]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LER OCA]. <br>
 +
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
 +
== Publication Abstract from PubMed ==
 +
A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possible conformations: globular (pc16a_1) and ribbon (pc16a_2). pc16a_1 co-eluted with the native peptide, which indicates a disulfide connectivity I-III, II-IV. The structure of pc16a_1 was determined by NMR. Both synthetic peptides were used to elucidate the biological activity. Bioassays were performed on crickets, ghost shrimps, larvae of the mealworm beetle and mice, but no effect was seen. Using two-electrode voltage clamp, a range of voltage-gated ion channels (Na(v) and K(v)) and nicotinic acetylcholine receptors were screened, but again no activity was found. Hence, the specific target of pc16a still remains to be discovered.
-
<!--
+
Pc16a, the first characterized peptide from Conus pictus venom, shows a novel disulfide connectivity.,Van Der Haegen A, Peigneur S, Dyubankova N, Moller C, Mari F, Diego-Garcia E, Naude R, Lescrinier E, Herdewijn P, Tytgat J Peptides. 2012 Mar;34(1):106-13. Epub 2011 Nov 3. PMID:22079220<ref>PMID:22079220</ref>
-
The line below this paragraph, containing "STRUCTURE_2ler", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_2ler| PDB=2ler | SCENE= }}
+
-
===Conotoxin pc16a===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
== References ==
-
 
+
<references/>
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_22079220}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 22079220 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_22079220}}
+
-
 
+
-
==About this Structure==
+
-
[[2ler]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LER OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:022079220</ref><references group="xtra"/>
+
[[Category: Dyubankova, N.]]
[[Category: Dyubankova, N.]]
[[Category: Haegen, A Van Der.]]
[[Category: Haegen, A Van Der.]]

Revision as of 08:29, 30 April 2014

Conotoxin pc16a

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ler"
Personal tools