2lk2

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[[Image:2lk2.png|left|200px]]
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==Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B==
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<StructureSection load='2lk2' size='340' side='right' caption='[[2lk2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<!--
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== Structural highlights ==
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The line below this paragraph, containing "STRUCTURE_2lk2", creates the "Structure Box" on the page.
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[[2lk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK2 OCA]. <br>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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== Disease ==
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[[http://www.uniprot.org/uniprot/TGIF1_HUMAN TGIF1_HUMAN]] Septopreoptic holoprosencephaly;Semilobar holoprosencephaly;Lobar holoprosencephaly;Alobar holoprosencephaly;Midline interhemispheric variant of holoprosencephaly;Microform holoprosencephaly. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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{{STRUCTURE_2lk2| PDB=2lk2 | SCENE= }}
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[[http://www.uniprot.org/uniprot/TGIF1_HUMAN TGIF1_HUMAN]] Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
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== References ==
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===Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B===
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<references/>
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__TOC__
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</StructureSection>
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==About this Structure==
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[[2lk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK2 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Acton, T B.]]
[[Category: Acton, T B.]]

Revision as of 08:39, 30 April 2014

Solution NMR structure of homeobox domain (171-248) of human homeobox protein TGIF1, Northeast Structural Genomics Consortium Target HR4411B

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