2je1

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[[Image:2je1.png|left|200px]]
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==THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS==
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<StructureSection load='2je1' size='340' side='right' caption='[[2je1]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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== Structural highlights ==
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[[2je1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE1 OCA]. <br>
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<b>Related:</b> [[2je0|2je0]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/je/2je1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
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The tumor suppressor protein pp32 is highly overexpressed in many cancers of the breast and prostate, and has also been implicated in the neurodegenerative disease spinocerebellar ataxias type 1 (SCA1). Pp32 is a multifunctional protein that is involved in the regulation of transcription, apoptosis, phosphorylation, and cell cycle progression, the latter through its association with the hyperphosphorylated form of the retinoblastoma tumor suppressor. We have determined the structure of an N-terminal pp32 fragment comprising a capped leucine-rich repeat (LRR) domain, which provides insight into the structural and biochemical properties of the pp32 (Anp32) family of proteins.
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The crystal structure of the tumor suppressor protein pp32 (Anp32a): structural insights into Anp32 family of proteins.,Huyton T, Wolberger C Protein Sci. 2007 Jul;16(7):1308-15. Epub 2007 Jun 13. PMID:17567741<ref>PMID:17567741</ref>
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The line below this paragraph, containing "STRUCTURE_2je1", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2je1| PDB=2je1 | SCENE= }}
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===THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_17567741}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 17567741 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_17567741}}
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==About this Structure==
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[[2je1]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JE1 OCA].
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==Reference==
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<ref group="xtra">PMID:017567741</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Huyton, T.]]
[[Category: Huyton, T.]]

Revision as of 08:42, 30 April 2014

THE CRYSTAL STRUCTURE OF THE TUMOR SUPRESSOR PROTEIN PP32 (ANP32A):STRUCTURAL INSIGHTS INTO THE ANP32 FAMILY OF PROTEINS

2je1, resolution 2.69Å

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