2j8i

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[[Image:2j8i.png|left|200px]]
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==STRUCTURE OF NP275, A PENTAPEPTIDE REPEAT PROTEIN FROM NOSTOC PUNCTIFORME==
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<StructureSection load='2j8i' size='340' side='right' caption='[[2j8i]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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[[2j8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_punctiforme Nostoc punctiforme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8I OCA]. <br>
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<b>Related:</b> [[2j8k|2j8k]]<br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j8/2j8i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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== Publication Abstract from PubMed ==
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The Nostoc punctiforme genes Np275 and Np276 are two adjacently encoded proteins of 98 and 75 amino acids in length and exhibit sequences composed of tandem pentapeptide repeats. The structures of Np275 and a fusion of Np275 and Np276 were determined to 2.1 and 1.5 A, respectively. The two Nostoc proteins fold as highly symmetric right-handed quadrilateral beta-helices similar to the mycobacterial protein MfpA implicated in fluoroquinolone resistance and DNA gyrase inhibition. The sequence composition of the intervening coding region and the ability to express a fused protein by removing the stop codon for Np275 suggests Np275 and Np276 were recently part of a larger ancestral pentapeptide repeat protein.
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Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein.,Vetting MW, Hegde SS, Hazleton KZ, Blanchard JS Protein Sci. 2007 Apr;16(4):755-60. PMID:17384236<ref>PMID:17384236</ref>
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The line below this paragraph, containing "STRUCTURE_2j8i", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2j8i| PDB=2j8i | SCENE= }}
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===STRUCTURE OF NP275, A PENTAPEPTIDE REPEAT PROTEIN FROM NOSTOC PUNCTIFORME===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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__TOC__
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The line below this paragraph, {{ABSTRACT_PUBMED_17384236}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 17384236 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_17384236}}
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==About this Structure==
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[[2j8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Nostoc_punctiforme Nostoc punctiforme]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J8I OCA].
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==Reference==
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<ref group="xtra">PMID:017384236</ref><references group="xtra"/>
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[[Category: Nostoc punctiforme]]
[[Category: Nostoc punctiforme]]
[[Category: Blanchard, J S.]]
[[Category: Blanchard, J S.]]

Revision as of 08:46, 30 April 2014

STRUCTURE OF NP275, A PENTAPEPTIDE REPEAT PROTEIN FROM NOSTOC PUNCTIFORME

2j8i, resolution 2.10Å

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