2ljm

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[[Image:2ljm.jpg|left|200px]]
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==Solution Structure of CssII==
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<StructureSection load='2ljm' size='340' side='right' caption='[[2ljm]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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== Structural highlights ==
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[[2ljm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_suffusus_suffusus Centruroides suffusus suffusus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJM OCA]. <br>
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<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br>
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== Publication Abstract from PubMed ==
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The three-dimensional structures of the long-chain mammalian scorpion beta-toxin CssII from Centruroides suffusus suffusus and of its recombinant form, HisrCssII, were determined by NMR. The neurotoxin CssII (nCssII) is a 66 amino acid long peptide with four disulfide bridges; it is the most abundant and deadly toxin from the venom of this scorpion. Both native and recombinant CssII structures were determined by nuclear magnetic resonance using a total of 828 sequential distance constraints derived from the volume integration of the cross peaks observed in 2D NOESY spectra. Both nCssII and HisrCssII structures display a mixed alpha/beta fold stabilized by four disulfide bridges formed between pairs of cysteines: C1-C8, C2-C5, C3-C6, and C4-C7 (the numbers indicate the relative positions of the cysteine residues in the primary structure), with a distortion induced by two cis-prolines in its C-terminal part. The native CssII electrostatic surface was compared to both the recombinant one and to the Cn2 toxin, from the scorpion Centruroides noxius, which is also toxic to mammals. Structural features such N- and C-terminal differences could influence toxin specificity and affinity towards isoforms of different sub-types of Na(v) channels.
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Solution structure of native and recombinant expressed toxin CssII from the venom of the scorpion Centruroides suffusus suffusus, and their effects on Nav1.5 Sodium channels.,Saucedo AL, Del Rio-Portilla F, Picco C, Estrada G, Prestipino G, Possani LD, Delepierre M, Corzo G Biochim Biophys Acta. 2012 Mar;1824(3):478-87. Epub 2012 Jan 11. PMID:22251893<ref>PMID:22251893</ref>
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The line below this paragraph, containing "STRUCTURE_2ljm", creates the "Structure Box" on the page.
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{{STRUCTURE_2ljm| PDB=2ljm | SCENE= }}
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===Solution Structure of CssII===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22251893}}, adds the Publication Abstract to the page
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 22251893 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22251893}}
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==About this Structure==
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[[2ljm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Centruroides_suffusus_suffusus Centruroides suffusus suffusus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJM OCA].
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==Reference==
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<ref group="xtra">PMID:022251893</ref><references group="xtra"/>
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[[Category: Centruroides suffusus suffusus]]
[[Category: Centruroides suffusus suffusus]]
[[Category: Corzo, G.]]
[[Category: Corzo, G.]]

Revision as of 08:46, 30 April 2014

Solution Structure of CssII

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