2lf6
From Proteopedia
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[[2lf6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._phaseolicola_1448a Pseudomonas syringae pv. phaseolicola 1448a]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF6 OCA]. <br> | [[2lf6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseudomonas_syringae_pv._phaseolicola_1448a Pseudomonas syringae pv. phaseolicola 1448a]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LF6 OCA]. <br> | ||
<b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span><br> | ||
| + | <b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lf6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lf6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lf6 RCSB], [http://www.ebi.ac.uk/pdbsum/2lf6 PDBsum]</span><br> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL contains two structurally homologous yet functionally distinct domains. The N-terminal domain corresponds to the previously described Pto-binding domain, while the previously uncharacterised C-terminal domain spans residues 308-385. While structurally similar, these domains do not share significant sequence similarity and most importantly demonstrate significant differences in key residues involved in host protein recognition, suggesting that each of them targets a different host protein. | HopPmaL is a member of the HopAB family of type III effectors present in the phytopathogen Pseudomonas syringae. Using both X-ray crystallography and solution nuclear magnetic resonance, we demonstrate that HopPmaL contains two structurally homologous yet functionally distinct domains. The N-terminal domain corresponds to the previously described Pto-binding domain, while the previously uncharacterised C-terminal domain spans residues 308-385. While structurally similar, these domains do not share significant sequence similarity and most importantly demonstrate significant differences in key residues involved in host protein recognition, suggesting that each of them targets a different host protein. | ||
Revision as of 10:09, 30 April 2014
Solution NMR structure of HopABPph1448_220_320 from Pseudomonas syringae pv. phaseolicola str. 1448A, Midwest Center for Structural Genomics target APC40132.4 and Northeast Structural Genomics Consortium target PsT3A
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Categories: Pseudomonas syringae pv. phaseolicola 1448a | Arrowsmith, C H. | Garcia, M. | Houliston, S. | Joachimiak, A. | MCSG, Midwest Center for Structural Genomics. | Montelione, G T. | NESG, Northeast Structural Genomics Consortium. | OCSP, Ontario Centre for Structural Proteomics. | Savchenko, A. | Semesi, A. | Singer, A U. | Wu, B. | Yee, A. | Mcsg | Midwest center for structural genomic | Nesg | Northeast structural genomics consortium | Ocsp | Ontario centre for structural proteomic | Protein structure initiative | Psi-biology | Signaling protein | Structural genomic | Type iii effector
