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JMS/Sandbox21
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<StructureSection load='3fhi' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='3fhi' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <scene name='58/583419/Pka_reg/1'>The PKA catalytic unit (C) crystalized with the regulatory unit (R)</scene>, pdb structure [[3fhi]]<ref>PMID:15692043</ref>, is shown with small lobe in gray, large lobe in tan and regulatory unit in light blue. The residues from exon 1 <scene name='58/583419/Pka_reg/2'>are distant</scene> from the residues which bind to the regulatory unit R. The last three residues from exon 1 (residues # 13-15) are the only translated amino acids from first exon of pkaca that were well-crystalized in this structure. These three residues are <scene name='58/583419/Pka_reg/3'>distant from PKI-interacting residues</scene> - a second regulator/inhibitor of 'C', as well. This is also obvious from the pdb structure for the <scene name='58/583419/Pka_pki/1'>crystal of C bound to PKI</scene>, [[1atp]]<ref>PMID:15299527</ref>. | + | <scene name='58/583419/Pka_reg/1'>The PKA catalytic unit (C) crystalized with the regulatory unit (R)</scene>, pdb structure [[3fhi]]<ref>PMID:15692043</ref>, is shown with small lobe in gray, large lobe in tan and regulatory unit in light blue. The residues from exon 1 (labeled) <scene name='58/583419/Pka_reg/2'>are distant</scene> from the residues which bind to the regulatory unit R (shown in ball and stick). The last three residues from exon 1 (residues # 13-15) are the only translated amino acids from first exon of pkaca that were well-crystalized in this structure. These three residues are <scene name='58/583419/Pka_reg/3'>distant from PKI-interacting residues (with yellow halos)</scene> - a second regulator/inhibitor of 'C', as well. This is also obvious from the pdb structure for the <scene name='58/583419/Pka_pki/1'>crystal of C bound to PKI</scene>, [[1atp]]<ref>PMID:15299527</ref>. |
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 00:56, 1 May 2014
PKA and Regulators
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References
- ↑ Kim C, Xuong NH, Taylor SS. Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA. Science. 2005 Feb 4;307(5710):690-6. PMID:15692043 doi:307/5710/690
- ↑ Zheng J, Trafny EA, Knighton DR, Xuong NH, Taylor SS, Ten Eyck LF, Sowadski JM. 2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr. 1993 May 1;49(Pt 3):362-5. PMID:15299527 doi:10.1107/S0907444993000423
