4kel
From Proteopedia
(Difference between revisions)
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<StructureSection load='4kel' size='340' side='right' caption='[[4kel]], [[Resolution|resolution]] 1.15Å' scene=''> | <StructureSection load='4kel' size='340' side='right' caption='[[4kel]], [[Resolution|resolution]] 1.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | [[4kel]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEL OCA]. <br> | + | <table><tr><td colspan='2'>[[4kel]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEL OCA]. <br> |
| - | <b>[[Related_structure|Related:]]</b> [[2bdg|2bdg]], [[2bdi|2bdi]], [[2bdh|2bdh]], [[4k8y|4k8y]], [[4k1e|4k1e]], [[4kga|4kga]]< | + | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2bdg|2bdg]], [[2bdi|2bdi]], [[2bdh|2bdh]], [[4k8y|4k8y]], [[4k1e|4k1e]], [[4kga|4kga]]</td></tr> |
| - | <b>Activity:</b> <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span>< | + | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr> |
| - | <b>Resources:</b> <span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kel RCSB], [http://www.ebi.ac.uk/pdbsum/4kel PDBsum]</span>< | + | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kel OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kel RCSB], [http://www.ebi.ac.uk/pdbsum/4kel PDBsum]</span></td></tr> |
| + | <table> | ||
== Disease == | == Disease == | ||
[[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref> | [[http://www.uniprot.org/uniprot/KLK4_HUMAN KLK4_HUMAN]] Defects in KLK4 are the cause of amelogenesis imperfecta hypomaturation type 2A1 (AI2A1) [MIM:[http://omim.org/entry/204700 204700]]. AI2A1 is an autosomal recessive defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel.<ref>PMID:15235027</ref> | ||
Revision as of 09:25, 1 May 2014
Atomic resolution crystal structure of Kallikrein-Related Peptidase 4 complexed with a modified SFTI inhibitor FCQR(N)
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