JMS/Sandbox21

<scene name='58/583419/Pka_reg/1'>The PKA catalytic unit (C) crystalized with the regulatory unit (R)</scene>, pdb structure [[3fhi]]<ref>PMID:15692043</ref>, is shown with small lobe in gray, large lobe in tan and regulatory unit in light blue. The residues from exon 1 (labeled) <scene name='58/583419/Pka_reg/2'>are distant</scene> from the residues which bind to the regulatory unit R (shown in ball and stick). The last three residues from exon 1 (residues # 13-15) are the only translated amino acids from first exon of pkaca that were well-crystalized in this structure. These three residues are <scene name='58/583419/Pka_reg/3'>distant from PKI-interacting residues (with yellow halos)</scene> - a second regulator/inhibitor of 'C', as well. This is also obvious from the pdb structure for the <scene name='58/583419/Pka_pki/1'>crystal of C bound to PKI</scene>, [[1atp]]<ref>PMID:15299527</ref>.