User:A. Rahim Zalal/Sandbox 1
From Proteopedia
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== Structure == | == Structure == | ||
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<StructureSection load='1aoi' size='340' side='right' caption='Histone Complexed with DNA to form Nucleosome' scene=''> | <StructureSection load='1aoi' size='340' side='right' caption='Histone Complexed with DNA to form Nucleosome' scene=''> | ||
This is a default text for your page '''A. Rahim Zalal/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page '''A. Rahim Zalal/Sandbox 1'''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
| - | </StructureSection> | + | </StructureSection>--> |
== Function == | == Function == | ||
Revision as of 17:23, 2 May 2014
Histone (H2A)
The histone proteins are a family of proteins that allow for the compaction of DNA into functional units known as nucleosomes, which, through certain organized arrangements, form the chromatin fibers in eukaryotic organisms. The histone family includes the core histone families, H2A, H2B, H3, and H4, as well as the linker histone family, H1. The core histone proteins form the core of the nucleosome, while the linker histones sit on the outside of the nucleosome subunit and assist in interactions with other nucleosomes within the chromatin.
Contents |
Structure
Function
Sequence
Protein Primary Sequence
The sequence for histone H2A type 1 (human) is presented here[1]:
10 20 30 40 50 60
MSGRGKQGGK ARAKAKTRSS RAGLQFPVGR VHRLLRKGNY AERVGAGAPV YLAAVLEYLT
70 80 90 100 110 120
AEILELAGNA ARDNKKTRII PRHLQLAIRN DEELNKLLGK VTIAQGGVLP NIQAVLLPKK
130
TESHHKAKGK
Coding DNA Sequence
The coding DNA sequence for the H2A type 1 subunit (human)[2]:
ENA|AAA63191|AAA63191.1 Homo sapiens (human) histone H2A.1 : Location:1..393 ATGTCTGGACGTGGAAAGCAAGGCGGCAAAGCTCGGGCAAAAGCTAAAACGCGTTCTTCC AGGGCCGGTCTTCAGTTTCCAGTTGGCCGTGTGCACCGCCTCCTCCGCAAAGGCAACTAC TCCGAACGAGTCGGGGCCGGCGCTCCAGTGTACCTGGCAGCGGTGCTGGAATATCTGACG GCCGAGATCTTAGAGCTAGCTGGCAACGCGGCTCGCGACAATAAGAAGACCCGCATCATC CCGCGCCACCTGCAGCTAGCCATCCGCAACGACGAGGAGCTAAATAAGCTTCTAGGTCGC GTGACCATCGCGCAGGGCGGTGTCCTGCCCAACATCCAGGCCGTATTGCTGCCTAAGAAG ACGGAGAGCCACCATAAGGCCAAGGGCAAGTGA
Mechanism
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
References
- ↑ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ. The human and mouse replication-dependent histone genes. Genomics. 2002 Nov;80(5):487-98. PMID:12408966
- ↑ Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D. Isolation and characterization of two human H1 histone genes within clusters of core histone genes. Genomics. 1991 Aug;10(4):940-8. PMID:1916825
