This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
User:Yunlong Zhao/Sandbox 1
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Introduction== | ==Introduction== | ||
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | + | Antithrombin and thrombin interactions play an important role in multiple functions. Interestingly, an heparin or polysaccharides can regulate the function of antithrombin to different signaling. <ref>DOI 10.1021/bi034524y</ref> | |
| - | + | ||
| - | == | + | == Heparin Binding site on antithrombin == |
| - | + | Green scene 1 will be a antithrombin specific site for binding heparin | |
| + | Green scene 2 will be the complex with heparin | ||
| - | == | + | == The mechanism of heparin regulating antithrombin thrombin interaction == |
| + | |||
| + | Green scene 1 will be the interface between AT and thrombin | ||
| + | Green scene 2 will be the the interface structure plus heparin | ||
| - | == Structural highlights == | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 17:54, 5 May 2014
Introduction
| |||||||||||
References
- ↑ Johnson DJ, Huntington JA. Crystal structure of antithrombin in a heparin-bound intermediate state. Biochemistry. 2003 Jul 29;42(29):8712-9. PMID:12873131 doi:10.1021/bi034524y
