4or8

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{{STRUCTURE_4or8| PDB=4or8 | SCENE= }}
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==Crystal structure of Marburg virus VP24==
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===Crystal structure of Marburg virus VP24===
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<StructureSection load='4or8' size='340' side='right' caption='[[4or8]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4or8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lake_victoria_marburgvirus_(strain_musoke-80) Lake victoria marburgvirus (strain musoke-80)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OR8 OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP24 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=33727 Lake Victoria marburgvirus (strain Musoke-80)])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4or8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4or8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4or8 RCSB], [http://www.ebi.ac.uk/pdbsum/4or8 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting beta-shelf and an alternate conformation of the N-terminal polypeptide.
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==Function==
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Crystal Structure of Marburg Virus VP24.,Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO J Virol. 2014 May;88(10):5859-63. doi: 10.1128/JVI.03565-13. Epub 2014 Feb 26. PMID:24574400<ref>PMID:24574400</ref>
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[[http://www.uniprot.org/uniprot/VP24_MABVM VP24_MABVM]] May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.
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==About this Structure==
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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[[4or8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OR8 OCA].
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Abelson, D.]]
[[Category: Abelson, D.]]
[[Category: Bornholdt, Z.]]
[[Category: Bornholdt, Z.]]

Revision as of 06:58, 7 May 2014

Crystal structure of Marburg virus VP24

4or8, resolution 2.65Å

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