4q0n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4q0n" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==
-
 
+
<StructureSection load='4q0n' size='340' side='right' caption='[[4q0n]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
-
The entry 4q0n is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4q0n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0N OCA]. <br>
-
Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Monteiro, O., Fedorov, O., Chaikuad, A., Yue, W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XD:(2E)-1-(2-HYDROXYPHENYL)-3-(2,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDIN-6-YL)PROP-2-EN-1-ONE'>2XD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
-
 
+
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0o|4q0o]]</td></tr>
-
Description: Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
+
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0n RCSB], [http://www.ebi.ac.uk/pdbsum/4q0n PDBsum]</span></td></tr>
 +
<table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H.]]
 +
[[Category: Bountra, C.]]
 +
[[Category: Chaikuad, A.]]
 +
[[Category: Delft, F von.]]
 +
[[Category: Edwards, A M.]]
 +
[[Category: Fedorov, O.]]
 +
[[Category: Felletar, I.]]
 +
[[Category: Filippakopoulos, P.]]
 +
[[Category: Knapp, S.]]
 +
[[Category: Martin, S.]]
 +
[[Category: Monteiro, O.]]
 +
[[Category: Picaud, S.]]
 +
[[Category: SGC, Structural Genomics Consortium.]]
 +
[[Category: Yue, W.]]
 +
[[Category: Baf180]]
 +
[[Category: Brg1-associated factor 180]]
 +
[[Category: Bromodomain]]
 +
[[Category: Chromatin regulator]]
 +
[[Category: Dna-binding]]
 +
[[Category: Nucleus]]
 +
[[Category: Pb1]]
 +
[[Category: Pbrm1]]
 +
[[Category: Polybromo 1 isoform 1]]
 +
[[Category: Polybromo-1d]]
 +
[[Category: Sgc]]
 +
[[Category: Structural genomics consortium]]
 +
[[Category: Transcription]]
 +
[[Category: Transcription regulation]]

Revision as of 08:24, 7 May 2014

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

4q0n, resolution 1.78Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4q0n"
Views
Personal tools
Navigation
Toolbox