This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4q0n

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "4q0n" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
==Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand==
-
 
+
<StructureSection load='4q0n' size='340' side='right' caption='[[4q0n]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
-
The entry 4q0n is ON HOLD
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[4q0n]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q0N OCA]. <br>
-
Authors: Filippakopoulos, P., Picaud, S., Felletar, I., Martin, S., Monteiro, O., Fedorov, O., Chaikuad, A., Yue, W., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)
+
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XD:(2E)-1-(2-HYDROXYPHENYL)-3-(2,4,5,7-TETRAHYDRO-6H-PYRAZOLO[3,4-C]PYRIDIN-6-YL)PROP-2-EN-1-ONE'>2XD</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
-
 
+
<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q0o|4q0o]]</td></tr>
-
Description: Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand
+
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q0n RCSB], [http://www.ebi.ac.uk/pdbsum/4q0n PDBsum]</span></td></tr>
 +
<table>
 +
== Disease ==
 +
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Defects in PBRM1 are a cause of renal cell carcinoma (RCC) [MIM:[http://omim.org/entry/144700 144700]]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.<ref>PMID:21248752</ref>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/PB1_HUMAN PB1_HUMAN]] Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Acts as a negative regulator of cell proliferation.<ref>PMID:21248752</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Arrowsmith, C H.]]
 +
[[Category: Bountra, C.]]
 +
[[Category: Chaikuad, A.]]
 +
[[Category: Delft, F von.]]
 +
[[Category: Edwards, A M.]]
 +
[[Category: Fedorov, O.]]
 +
[[Category: Felletar, I.]]
 +
[[Category: Filippakopoulos, P.]]
 +
[[Category: Knapp, S.]]
 +
[[Category: Martin, S.]]
 +
[[Category: Monteiro, O.]]
 +
[[Category: Picaud, S.]]
 +
[[Category: SGC, Structural Genomics Consortium.]]
 +
[[Category: Yue, W.]]
 +
[[Category: Baf180]]
 +
[[Category: Brg1-associated factor 180]]
 +
[[Category: Bromodomain]]
 +
[[Category: Chromatin regulator]]
 +
[[Category: Dna-binding]]
 +
[[Category: Nucleus]]
 +
[[Category: Pb1]]
 +
[[Category: Pbrm1]]
 +
[[Category: Polybromo 1 isoform 1]]
 +
[[Category: Polybromo-1d]]
 +
[[Category: Sgc]]
 +
[[Category: Structural genomics consortium]]
 +
[[Category: Transcription]]
 +
[[Category: Transcription regulation]]

Revision as of 08:24, 7 May 2014

Crystal Structure of the fifth bromodomain of Human Poly-bromodomain containing protein 1 (PB1) in complex with a hydroxyphenyl-propenone ligand

4q0n, resolution 1.78Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4q0n"
Views
Personal tools
Navigation
Toolbox