2v7n

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[[Image:2v7n.png|left|200px]]
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==Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4==
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<StructureSection load='2v7n' size='340' side='right' caption='[[2v7n]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2v7n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7N OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v7n RCSB], [http://www.ebi.ac.uk/pdbsum/2v7n PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v7/2v7n_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The structure of the antibody Fab fragment f3p4, which was selected from a subset of the synthetic HuCAL antibody library to bind the sodium citrate symporter CitS, is described at 1.92 A resolution. Comparison with computational models revealed deviations in a few framework positions and in the binding loops. The crystals belong to space group P2(1)2(1)2 and contain four molecules in the asymmetric unit, with unit-cell parameters a=102.77, b=185.92, c=102.97 A. These particular unit-cell parameters allowed pseudo-merohedral twinning; interestingly, the twinning law relates a twofold screw axis to a twofold axis.
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<!--
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Structure of the recombinant antibody Fab fragment f3p4.,Frey D, Huber T, Pluckthun A, Grutter MG Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):636-43. Epub 2008 May 14. PMID:18560151<ref>PMID:18560151</ref>
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The line below this paragraph, containing "STRUCTURE_2v7n", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2v7n| PDB=2v7n | SCENE= }}
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===Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18560151}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18560151 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_18560151}}
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==About this Structure==
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[[2v7n]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7N OCA].
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==Reference==
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<ref group="xtra">PMID:018560151</ref><references group="xtra"/>
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[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
[[Category: Frey, D.]]
[[Category: Frey, D.]]

Revision as of 08:30, 7 May 2014

Unusual twinning in crystals of the CitS binding antibody Fab fragment f3p4

2v7n, resolution 1.92Å

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