2wst

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2wst.png|left|200px]]
+
==Head domain of porcine adenovirus type 4 NADC-1 isolate fibre==
 +
<StructureSection load='2wst' size='340' side='right' caption='[[2wst]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[2wst]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Porcine_adenovirus_4 Porcine adenovirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WST OCA]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wst FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wst OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wst RCSB], [http://www.ebi.ac.uk/pdbsum/2wst PDBsum]</span></td></tr>
 +
<table>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wst_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Adenovirus isolate NADC-1, a strain of porcine adenovirus type 4, has a fiber containing an N-terminal virus attachment region, shaft and head domains, and a C-terminal galectin domain connected to the head by an RGD-containing sequence. The crystal structure of the head domain is similar to previously solved adenovirus fiber head domains, but specific residues for binding the coxsackievirus and adenovirus receptor (CAR), CD46, or sialic acid are not conserved. The structure of the galectin domain reveals an interaction interface between its two carbohydrate recognition domains, locating both sugar binding sites face to face. Sequence evidence suggests other tandem-repeat galectins have the same arrangement. We show that the galectin domain binds carbohydrates containing lactose and N-acetyl-lactosamine units, and we present structures of the galectin domain with lactose, N-acetyl-lactosamine, 3-aminopropyl-lacto-N-neotetraose, and 2-aminoethyl-tri(N-acetyl-lactosamine), confirming the domain as a bona fide galectin domain.
-
<!--
+
Crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains.,Guardado-Calvo P, Munoz EM, Llamas-Saiz AL, Fox GC, Kahn R, Curiel DT, Glasgow JN, van Raaij MJ J Virol. 2010 Oct;84(20):10558-68. Epub 2010 Aug 4. PMID:20686025<ref>PMID:20686025</ref>
-
The line below this paragraph, containing "STRUCTURE_2wst", creates the "Structure Box" on the page.
+
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
-
or leave the SCENE parameter empty for the default display.
+
-
-->
+
-
{{STRUCTURE_2wst| PDB=2wst | SCENE= }}
+
-
===Head domain of porcine adenovirus type 4 NADC-1 isolate fibre===
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
 
+
</div>
-
 
+
== References ==
-
<!--
+
<references/>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20686025}}, adds the Publication Abstract to the page
+
__TOC__
-
(as it appears on PubMed at http://www.pubmed.gov), where 20686025 is the PubMed ID number.
+
</StructureSection>
-
-->
+
-
{{ABSTRACT_PUBMED_20686025}}
+
-
 
+
-
==About this Structure==
+
-
[[2wst]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Porcine_adenovirus_4 Porcine adenovirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WST OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:020686025</ref><ref group="xtra">PMID:008837892</ref><ref group="xtra">PMID:018756624</ref><ref group="xtra">PMID:019923738</ref><references group="xtra"/>
+
[[Category: Porcine adenovirus 4]]
[[Category: Porcine adenovirus 4]]
[[Category: Fox, G C.]]
[[Category: Fox, G C.]]

Revision as of 08:39, 7 May 2014

Head domain of porcine adenovirus type 4 NADC-1 isolate fibre

2wst, resolution 3.20Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2wst"
Views
Personal tools
Navigation
Toolbox