2vsq

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[[Image:2vsq.png|left|200px]]
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==STRUCTURE OF SURFACTIN A SYNTHETASE C (SRFA-C), A NONRIBOSOMAL PEPTIDE SYNTHETASE TERMINATION MODULE==
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<StructureSection load='2vsq' size='340' side='right' caption='[[2vsq]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2vsq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSQ OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LEU:LEUCINE'>LEU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jmk|1jmk]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vsq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2vsq RCSB], [http://www.ebi.ac.uk/pdbsum/2vsq PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vs/2vsq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Nonribosomal peptide synthetases (NRPS) are modularly organized megaenzymes that act as an assembly line to catalyze the biosynthesis of complex natural products. The crystal structure of the 144 kD termination module SrfA-C that comprises four essential domains was solved at 2.6 A resolution. Its architecture shows that the adenylation and condensation domains associate closely to form a catalytic platform with their active sites on the same side of the platform. The peptidyl-carrier domain is flexibly tethered to this platform and thus able to move with its substrate-loaded 4-phosphopantetheine arm between the active site of the adenylation domain and the donor side of the condensation domain. Furthermore, the SrfA-C crystal structure inspires further investigations on rational redesign of NRPS for production of novel bioactive peptides.
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Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase.,Tanovic A, Samel SA, Essen LO, Marahiel MA Science. 2008 Jun 26;. PMID:18583577<ref>PMID:18583577</ref>
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The line below this paragraph, containing "STRUCTURE_2vsq", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2vsq| PDB=2vsq | SCENE= }}
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===STRUCTURE OF SURFACTIN A SYNTHETASE C (SRFA-C), A NONRIBOSOMAL PEPTIDE SYNTHETASE TERMINATION MODULE===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18583577}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18583577 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18583577}}
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==About this Structure==
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[[2vsq]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VSQ OCA].
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==See Also==
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*[[User:Jaime Prilusky/Motif|User:Jaime Prilusky/Motif]]
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==Reference==
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<ref group="xtra">PMID:018583577</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Essen, L O.]]
[[Category: Essen, L O.]]

Revision as of 08:40, 7 May 2014

STRUCTURE OF SURFACTIN A SYNTHETASE C (SRFA-C), A NONRIBOSOMAL PEPTIDE SYNTHETASE TERMINATION MODULE

2vsq, resolution 2.60Å

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OCA

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