2lpw

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[[Image:2lpw.png|left|200px]]
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==human CEB25 minisatellite G-quadruplex==
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<StructureSection load='2lpw' size='340' side='right' caption='[[2lpw]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2lpw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPW OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2kyo|2kyo]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lpw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2lpw RCSB], [http://www.ebi.ac.uk/pdbsum/2lpw PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CEB25 is a human minisatellite locus, composed of slightly polymorphic 52-nucleotide (nt) tandem repeats. Genetically, most if not all individuals of the human population are heterozygous, carrying alleles ranging from 0.5 to 20 kb, maintained by mendelian inheritance but also subject to germline instability. To provide insights on the biological role of CEB25, we interrogated its structural features. We report the NMR structure of the G-quadruplex formed by the conserved 26-nt G-rich fragment of the CEB25 motif. In K(+) solution, this sequence forms a propeller-type parallel-stranded G-quadruplex involving a 9-nt central double-chain-reversal loop. This long loop is anchored to the 5'-end of the sequence by an A.T Watson-Crick base pair and a potential G.A noncanonical base pair. These base pairs contribute to the stability of the overall G-quadruplexstructure, as measured by an increase of about 17 kcal/mol in enthalpy or 6 degrees C in melting temperature. Further, we demonstrate that such a monomorphic structure is formed within longer sequence contexts folding into a pearl-necklace structure.
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Formation of Pearl-Necklace Monomorphic G-Quadruplexes in the Human CEB25 Minisatellite.,Amrane S, Adrian M, Heddi B, Serero A, Nicolas A, Mergny JL, Phan AT J Am Chem Soc. 2012 Apr 4;134(13):5807-16. Epub 2012 Mar 26. PMID:22376028<ref>PMID:22376028</ref>
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The line below this paragraph, containing "STRUCTURE_2lpw", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2lpw| PDB=2lpw | SCENE= }}
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===human CEB25 minisatellite G-quadruplex===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22376028}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22376028 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22376028}}
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==About this Structure==
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[[2lpw]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LPW OCA].
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==Reference==
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<ref group="xtra">PMID:022376028</ref><references group="xtra"/>
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[[Category: Adrian, M.]]
[[Category: Adrian, M.]]
[[Category: Amrane, S.]]
[[Category: Amrane, S.]]

Revision as of 08:43, 7 May 2014

human CEB25 minisatellite G-quadruplex

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