User:Jaakko Itkonen
From Proteopedia
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==References== | ==References== | ||
| - | Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GCA, Gascan H | + | Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GCA, Gascan H and Gauchat J-F: Expression of biologically active mouse ciliary neurotrophic factor (CNTF) and soluble CNTFRα in Eschericia coli and characterization of their functional specificities. Eur Cytokine Netw 15: 255-262 (2004). |
| - | Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM | + | Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM and Wen R: CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 5: 1-7 (2010). |
| - | Li Y, Wen R, Banzon T, Maminishkis A | + | Li Y, Wen R, Banzon T, Maminishkis A and Miller SS: CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One 6: 1-7 (2011). |
| - | McDonald NQ, Panayotatos N | + | McDonald NQ, Panayotatos N and Hendrickson WA: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J 14: 2689-2699 (1995). |
Richardson PM: Ciliary neurotrophic factor: A review. Pharmac Ther 63: 187-198 (1994). | Richardson PM: Ciliary neurotrophic factor: A review. Pharmac Ther 63: 187-198 (1994). | ||
| - | Sieving PA, Caruse RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR | + | Sieving PA, Caruse RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR and Bush RA: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. PNAS 103: 3896-3901 (2006). |
| - | Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD | + | Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD and Wiegand SJ: The ciliary neurotrophic factor and its receptor, CNTFRα. Pharm Acta Helv 74: 265-272 (2000). |
| - | Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM | + | Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM and Sieving PA: Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26: 13523-13530 (2006). |
| - | Wen R, Tao W, Li Y | + | Wen R, Tao W, Li Y and Sieving PA: CNTF and retina. Prog Retin Eye Res 31: 136-151 (2012). |
Revision as of 12:00, 7 May 2014
- Full Real Name: Jaakko Matias Itkonen
- Position: Student
- Institution (NO ABBREVIATIONS): University of Helsinki, Faculty Of Pharmacy, Division of Pharmaceutical Biosciences
- City, State/Province, Country: Helsinki, Finland
- Field of Expertise or Study: Pharmacy
Contents |
Introduction
Ciliary neutrophic factor (CNTF) is a nerve growth factor belonging to the interleukin-6 family of neuropoietic cytokines. Other members of this family include leukaemie inhibitory factor (LIF), IL-6, IL-11 and oncostatin M (Wang 2012).
Fig. 1 X-ray structure of a truncated form of hCNTF (2-187)
Structure
Overview
CNTF is a roughly 22.7 kDa protein consisting of a single polypeptide chain of 200 amino acid residues. Like with many other cytokines, the tertiary structure of CNTF consists of four anti-parallel α-helices (A-D), where helices A-B and C-D are connected by two cross-over loops and helices B-C by one short loop.
Disease
References
Cognet I, Guilhot F, Chevalier S, Guay-Giroux A, Bert A, Elson GCA, Gascan H and Gauchat J-F: Expression of biologically active mouse ciliary neurotrophic factor (CNTF) and soluble CNTFRα in Eschericia coli and characterization of their functional specificities. Eur Cytokine Netw 15: 255-262 (2004).
Li Y, Tao W, Luo L, Huang D, Kauper K, Stabila P, LaVail MM, Laties AM and Wen R: CNTF induces regeneration of cone outer segments in a rat model of retinal degeneration. PLoS One 5: 1-7 (2010).
Li Y, Wen R, Banzon T, Maminishkis A and Miller SS: CNTF mediates neurotrophic factor secretion and fluid absorption in human retinal pigment epithelium. PLoS One 6: 1-7 (2011).
McDonald NQ, Panayotatos N and Hendrickson WA: Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J 14: 2689-2699 (1995).
Richardson PM: Ciliary neurotrophic factor: A review. Pharmac Ther 63: 187-198 (1994).
Sieving PA, Caruse RC, Tao W, Coleman HR, Thompson DJS, Fullmer KR and Bush RA: Ciliary neurotrophic factor (CNTF) for human retinal degeneration: Phase I trial of CNTF delivered by encapsulated cell intraocular implants. PNAS 103: 3896-3901 (2006).
Sleeman MW, Anderson KD, Lambert PD, Yancopoulos GD and Wiegand SJ: The ciliary neurotrophic factor and its receptor, CNTFRα. Pharm Acta Helv 74: 265-272 (2000).
Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM and Sieving PA: Regulation of rod phototransduction machinery by ciliary neurotrophic factor. J Neurosci 26: 13523-13530 (2006).
Wen R, Tao W, Li Y and Sieving PA: CNTF and retina. Prog Retin Eye Res 31: 136-151 (2012).
