Neprilysin
From Proteopedia
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<StructureSection load='1dmt' size='400' side='right' caption='Structure of human neprilysin extracellular domain complex with phosphoramidon (PDB entry [[1dmt]])' scene=''> | <StructureSection load='1dmt' size='400' side='right' caption='Structure of human neprilysin extracellular domain complex with phosphoramidon (PDB entry [[1dmt]])' scene=''> | ||
| - | '''Neprilysin''' (NEP) is a Zn-dependent metalloprotease which degrades small secreted peptides like the beta-amyloid peptide. NEP turns off peptide signalling events at the cell surface. | + | '''Neprilysin''' (NEP), also known as '''neutral endopeptidase''', is a Zn-dependent metalloprotease which degrades small secreted peptides like the beta-amyloid peptide, tachykinin, neurotensin and enkephalins.<ref>PMID: 15134871</ref><ref>PMID: 15544569</ref><ref>PMID: 17476590</ref><ref>PMID: 18393807</ref><ref>PMID: 18470479</ref><ref>PMID: 23684647</ref><ref>PMID: 23883611</ref><ref>PMID: 24391587</ref> Its signalling has also been implicated in cardiovascular disease.<ref>PMID: 21046489</ref> NEP turns off peptide signalling events at the cell surface. NEP is found in brain tissue and is an integral membrane protein. |
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==3D structures of neprilysin== | ==3D structures of neprilysin== | ||
Revision as of 12:59, 7 May 2014
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