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Spermidine Synthase
From Proteopedia
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==3D structures of spermidine synthase== | ==3D structures of spermidine synthase== | ||
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| + | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[1inl]] – TmSPS – ''Thermotoga maritima''<br /> | [[1inl]] – TmSPS – ''Thermotoga maritima''<br /> | ||
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[[2cmg]], [[2cmh]] – SPS – ''Helicobacter pylori''<br /> | [[2cmg]], [[2cmh]] – SPS – ''Helicobacter pylori''<br /> | ||
[[2pss]] – PfSPS – ''Plasmodium falciparum''<br /> | [[2pss]] – PfSPS – ''Plasmodium falciparum''<br /> | ||
| - | [[3o4f]] – SPS – ''Escherichia coli'' | + | [[3o4f]] – SPS – ''Escherichia coli''<br /> |
| + | [[3bwc]] - TcSPS – ''Trypanosoma cruzi''<br /> | ||
| - | Binary complexes of spermidine synthase | + | ===Binary complexes of spermidine synthase=== |
[[1jq3]] – TmSPS + transition state analog<br /> | [[1jq3]] – TmSPS + transition state analog<br /> | ||
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[[2pwp]] - PfSPS + spermidine<br /> | [[2pwp]] - PfSPS + spermidine<br /> | ||
[[3b7p]] - PfSPS + spermine<br /> | [[3b7p]] - PfSPS + spermine<br /> | ||
| - | [[3bwc]] - | + | [[3bwc]] - TcSPS + SAM <br /> |
| - | [[3rw9]] - hSPS + SAH | + | [[3rw9]] - hSPS + SAH<br /> |
| + | [[3anx]] – SPS + methylthioadenosine – ''Thermus thermophilus''<br /> | ||
| - | Ternary complexes of spermidine synthase | + | ===Ternary complexes of spermidine synthase=== |
[[3c6k]] - hSPS + methylthioadenosine + spermidine<br /> | [[3c6k]] - hSPS + methylthioadenosine + spermidine<br /> | ||
[[3c6m]] - hSPS + methylthioadenosine + spermine<br /> | [[3c6m]] - hSPS + methylthioadenosine + spermine<br /> | ||
| - | [[2pt6]], [[3rie]] - PfSPS + inhibitor + methylthioadenosine | + | [[2pt6]], [[3rie]] - PfSPS + inhibitor + methylthioadenosine<br /> |
| + | [[2pt9]] - PfSPS + inhibitor + SAM derivative<br /> | ||
Created with the participation of [[User:Lindsey Butler|Lindsey Butler]]. | Created with the participation of [[User:Lindsey Butler|Lindsey Butler]]. | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:48, 8 May 2014
Under construction!
Polyamines are essential in all branches of life. Spermidine synthase (putrescine aminopropyltransferase, PAPT) catalyzes the biosynthesis of spermidine, a ubiquitous polyamine. 1inl - The crystal structure of the PAPT from Thermotoga maritima (TmPAPT) has been solved to 1.5 A resolution. The structure of TmPAPT in a complex with adoDATO (1jq3) can also be found on this site.
3D structures of spermidine synthase
Updated on 08-May-2014
1inl – TmSPS – Thermotoga maritima
1mjf – SPS – Pyrococcus furiosus
2e5w, 2zsu - SPS – Pyrococcus horikishii
1iy9 – SPS – Bacillus subtilis
1xj5, 2q41 – SPS – Arabidopsis thaliana
2b2c – SPS – Caenorhabditis elegans
2o05, 2o06, 2o07, 2o0l – SPS – human
2cmg, 2cmh – SPS – Helicobacter pylori
2pss – PfSPS – Plasmodium falciparum
3o4f – SPS – Escherichia coli
3bwc - TcSPS – Trypanosoma cruzi
Binary complexes of spermidine synthase
1jq3 – TmSPS + transition state analog
2hte, 2pt6 - PfSPS + methylthioadenosine
2i7c - PfSPS + transition state analog
2pwp - PfSPS + spermidine
3b7p - PfSPS + spermine
3bwc - TcSPS + SAM
3rw9 - hSPS + SAH
3anx – SPS + methylthioadenosine – Thermus thermophilus
Ternary complexes of spermidine synthase
3c6k - hSPS + methylthioadenosine + spermidine
3c6m - hSPS + methylthioadenosine + spermine
2pt6, 3rie - PfSPS + inhibitor + methylthioadenosine
2pt9 - PfSPS + inhibitor + SAM derivative
Created with the participation of Lindsey Butler.
