3v7o

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
{{STRUCTURE_3v7o| PDB=3v7o | SCENE= }}
+
==Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)==
-
===Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)===
+
<StructureSection load='3v7o' size='340' side='right' caption='[[3v7o]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[3v7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA]. <br>
 +
</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene><br>
 +
<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">VP30 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=386032 EBORR])</td></tr>
 +
<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
 +
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v7o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3v7o RCSB], [http://www.ebi.ac.uk/pdbsum/3v7o PDBsum]</span></td></tr>
 +
<table>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The ebolaviruses can cause severe hemorrhagic fever. Essential to the ebolavirus life cycle is the protein VP30, which serves as a transcriptional cofactor. Here, the crystal structure of the C-terminal, NP-binding domain of VP30 from Reston ebolavirus is presented. Reston VP30 and Ebola VP30 both form homodimers, but the dimeric interfaces are rotated relative to each other, suggesting subtle inherent differences or flexibility in the dimeric interface.
-
==Function==
+
Structure of the Reston ebolavirus VP30 C-terminal domain.,Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi:, 10.1107/S2053230X14003811. Epub 2014 Mar 25. PMID:24699737<ref>PMID:24699737</ref>
-
[[http://www.uniprot.org/uniprot/VP30_EBORR VP30_EBORR]] Acts as a transcription anti-termination factor immediately after transcription initiation, but does not affect transcription elongation. This function has been found to be dependent on the formation of an RNA stem-loop at the transcription start site of the first gene. Binds to RNA (By similarity).
+
-
==About this Structure==
+
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-
[[3v7o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Eborr Eborr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V7O OCA].
+
</div>
-
 
+
== References ==
-
==See Also==
+
<references/>
-
*[[Nucleoprotein|Nucleoprotein]]
+
__TOC__
-
*[[Transcriptional activator|Transcriptional activator]]
+
</StructureSection>
[[Category: Eborr]]
[[Category: Eborr]]
[[Category: Disease, Seattle Structural Genomics Center for Infectious.]]
[[Category: Disease, Seattle Structural Genomics Center for Infectious.]]

Revision as of 06:50, 14 May 2014

Crystal structure of the C-terminal domain of Ebola virus VP30 (strain Reston-89)

3v7o, resolution 2.25Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3v7o"
Views
Personal tools
Navigation
Toolbox