2xbo

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[[Image:2xbo.png|left|200px]]
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==Equine Rhinitis A Virus in Complex with its Sialic Acid Receptor==
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<StructureSection load='2xbo' size='340' side='right' caption='[[2xbo]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xbo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_rhinitis_a_virus Equine rhinitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBO OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wff|2wff]], [[2ws9|2ws9]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xbo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xbo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xbo RCSB], [http://www.ebi.ac.uk/pdbsum/2xbo PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xb/2xbo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Equine rhinitis A virus (ERAV) shares many features with foot-and-mouth disease virus (FMDV) and both are classified within the genus Aphthovirus of the family Picornaviridae. ERAV is used as a surrogate for FMDV research as it does not require high-level biosecurity. In contrast to FMDV, which uses integrins as cellular receptors, the receptor for ERAV has been reported to involve the sugar moiety sialic acid. This study confirmed the importance of sialic acid for cell entry by ERAV and reports the crystal structure of ERAV particles complexed with the receptor analogue 3'-sialyllactose. The receptor is attached to the rim of a capsid pit adjacent to the major immunogenic site and distinct from the sialic acid binding site used by a related picornavirus, the cardiovirus Theiler's murine encephalitis virus. The structure of the major antigenic determinant of the virus, previously identified from antibody escape mutations, is also described as the EF loop of VP1, which forms a hairpin stretching across the capsid surface close to the icosahedral fivefold axis, neighbouring the receptor-binding site, and spanning two protomeric units.
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<!--
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Crystal structure of equine rhinitis A virus in complex with its sialic acid receptor.,Fry EE, Tuthill TJ, Harlos K, Walter TS, Rowlands DJ, Stuart DI J Gen Virol. 2010 Aug;91(Pt 8):1971-7. Epub 2010 Apr 28. PMID:20427563<ref>PMID:20427563</ref>
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The line below this paragraph, containing "STRUCTURE_2xbo", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2xbo| PDB=2xbo | SCENE= }}
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===Equine Rhinitis A Virus in Complex with its Sialic Acid Receptor===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_20427563}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20427563 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_20427563}}
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==About this Structure==
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[[2xbo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Equine_rhinitis_a_virus Equine rhinitis a virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XBO OCA].
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==Reference==
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<ref group="xtra">PMID:020427563</ref><references group="xtra"/>
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[[Category: Equine rhinitis a virus]]
[[Category: Equine rhinitis a virus]]
[[Category: Fry, E E.]]
[[Category: Fry, E E.]]

Revision as of 07:38, 14 May 2014

Equine Rhinitis A Virus in Complex with its Sialic Acid Receptor

2xbo, resolution 4.00Å

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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