2zc0

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[[Image:2zc0.png|left|200px]]
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==Crystal structure of an archaeal alanine:glyoxylate aminotransferase==
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<StructureSection load='2zc0' size='340' side='right' caption='[[2zc0]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2zc0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC0 OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PMP:4-DEOXY-4-AMINOPYRIDOXAL-5-PHOSPHATE'>PMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zc0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zc0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zc0 RCSB], [http://www.ebi.ac.uk/pdbsum/2zc0 PDBsum]</span></td></tr>
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<table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zc/2zc0_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The crystal structure of a novel alanine:glyoxylate aminotransferase from the hyperthermophilic archaeon Thermococcus litoralis was determined at 2.3 A resolution. The asymmetric unit contains four homologous subunits and the functional tetramer is generated by noncrystallographic 222 symmetry. Although the main-chain coordinates of the monomer of the Thermococcus litoralis enzyme showed a high degree of similarity to those of aspartate aminotransferase from Thermus thermophilus HB8, the amino-acid residues involved in substrate binding in the aspartate aminotransferase are only partially conserved in the Thermococcus litoralis enzyme. This may account for the difference in the substrate specificities of the two enzymes.
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<!--
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Structure of an archaeal alanine:glyoxylate aminotransferase.,Sakuraba H, Yoneda K, Takeuchi K, Tsuge H, Katunuma N, Ohshima T Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):696-9. Epub 2008 May 14. PMID:18560158<ref>PMID:18560158</ref>
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The line below this paragraph, containing "STRUCTURE_2zc0", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2zc0| PDB=2zc0 | SCENE= }}
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===Crystal structure of an archaeal alanine:glyoxylate aminotransferase===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<!--
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18560158}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18560158 is the PubMed ID number.
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</StructureSection>
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-->
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{{ABSTRACT_PUBMED_18560158}}
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==About this Structure==
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[[2zc0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermococcus_litoralis Thermococcus litoralis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZC0 OCA].
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==Reference==
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<ref group="xtra">PMID:018560158</ref><references group="xtra"/>
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[[Category: Alanine--glyoxylate transaminase]]
[[Category: Alanine--glyoxylate transaminase]]
[[Category: Thermococcus litoralis]]
[[Category: Thermococcus litoralis]]

Revision as of 07:39, 14 May 2014

Crystal structure of an archaeal alanine:glyoxylate aminotransferase

2zc0, resolution 2.30Å

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