2ybx

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[[Image:2ybx.png|left|200px]]
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==Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha==
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<StructureSection load='2ybx' size='340' side='right' caption='[[2ybx]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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== Structural highlights ==
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The line below this paragraph, containing "STRUCTURE_2ybx", creates the "Structure Box" on the page.
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<table><tr><td colspan='2'>[[2ybx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBX OCA]. <br>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene><br>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr>
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or leave the SCENE parameter empty for the default display.
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ybx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ybx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ybx RCSB], [http://www.ebi.ac.uk/pdbsum/2ybx PDBsum]</span></td></tr>
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{{STRUCTURE_2ybx| PDB=2ybx | SCENE= }}
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<table>
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== Disease ==
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===Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha===
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[[http://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN]] Precursor B-cell acute lymphoblastic leukemia.
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== Function ==
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[[http://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN]] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.<ref>PMID:18364242</ref>
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==About this Structure==
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== References ==
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[[2ybx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YBX OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
[[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]

Revision as of 07:39, 14 May 2014

Crystal Structure of Human Phosphatidylinositol-5-phosphate 4-kinase type-2 alpha

2ybx, resolution 2.56Å

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