2xxn

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[[Image:2xxn.png|left|200px]]
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==Structure of the vIRF4-HAUSP TRAF domain complex==
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<StructureSection load='2xxn' size='340' side='right' caption='[[2xxn]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xxn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXN OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f1z|2f1z]], [[2f1y|2f1y]], [[1nbf|1nbf]], [[2f1w|2f1w]], [[1nb8|1nb8]], [[2foj|2foj]], [[2fop|2fop]], [[2f1x|2f1x]], [[2foo|2foo]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xxn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xxn RCSB], [http://www.ebi.ac.uk/pdbsum/2xxn PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Herpesvirus-associated ubiquitin-specific protease (HAUSP) regulates the stability of p53 and the p53-binding protein MDM2, implicating HAUSP as a therapeutic target for tuning p53-mediated antitumor activity. Here we report the structural analysis of HAUSP with Kaposi's sarcoma-associated herpesvirus viral interferon (IFN) regulatory factor 4 (vIRF4) and the discovery of two vIRF4-derived peptides, vif1 and vif2, as potent and selective HAUSP antagonists. This analysis reveals a bilateral belt-type interaction that results in inhibition of HAUSP. The vif1 peptide binds the HAUSP TRAF domain, competitively blocking substrate binding, whereas the vif2 peptide binds both the HAUSP TRAF and catalytic domains, robustly suppressing its deubiquitination activity. Peptide treatments comprehensively blocked HAUSP, leading to p53-dependent cell-cycle arrest and apoptosis in culture and to tumor regression in xenograft mouse model. Thus, the virus has developed a unique strategy to target the HAUSP-MDM2-p53 pathway, and these virus-derived short peptides represent biologically active HAUSP antagonists.
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Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein.,Lee HR, Choi WC, Lee S, Hwang J, Hwang E, Guchhait K, Haas J, Toth Z, Jeon YH, Oh TK, Kim MH, Jung JU Nat Struct Mol Biol. 2011 Nov 6;18(12):1336-44. doi: 10.1038/nsmb.2142. PMID:22056774<ref>PMID:22056774</ref>
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The line below this paragraph, containing "STRUCTURE_2xxn", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2xxn| PDB=2xxn | SCENE= }}
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===Structure of the vIRF4-HAUSP TRAF domain complex===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22056774}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22056774 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22056774}}
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==About this Structure==
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[[2xxn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_8 Human herpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XXN OCA].
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==Reference==
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<ref group="xtra">PMID:022056774</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human herpesvirus 8]]
[[Category: Human herpesvirus 8]]

Revision as of 07:43, 14 May 2014

Structure of the vIRF4-HAUSP TRAF domain complex

2xxn, resolution 1.60Å

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