159d

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[[Image:159d.gif|left|200px]]<br /><applet load="159d" size="350" color="white" frame="true" align="right" spinBox="true"
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[[Image:159d.gif|left|200px]]
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caption="159d, resolution 1.800&Aring;" />
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'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''<br />
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{{Structure
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|PDB= 159d |SIZE=350|CAPTION= <scene name='initialview01'>159d</scene>, resolution 1.800&Aring;
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|SITE=
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|LIGAND= <scene name='pdbligand=DMY:DISTAMYCIN+A'>DMY</scene> and <scene name='pdbligand=MG:MAGNESIUM ION'>MG</scene>
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|ACTIVITY=
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|GENE=
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}}
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'''SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX'''
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==Overview==
==Overview==
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==About this Structure==
==About this Structure==
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159D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=DMY:'>DMY</scene> and <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
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159D is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=159D OCA].
==Reference==
==Reference==
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Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7656035 7656035]
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Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7656035 7656035]
[[Category: Protein complex]]
[[Category: Protein complex]]
[[Category: Chen, X.]]
[[Category: Chen, X.]]
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[[Category: modified]]
[[Category: modified]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:38:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:49:53 2008''

Revision as of 07:49, 20 March 2008

Image:159d.gif


PDB ID 159d

Drag the structure with the mouse to rotate
, resolution 1.800Å
Ligands: and
Coordinates: save as pdb, mmCIF, xml



SIDE BY SIDE BINDING OF TWO DISTAMYCIN A DRUGS IN THE MINOR GROOVE OF AN ALTERNATING B-DNA DUPLEX


Overview

Here we report the 1.8A X-ray structure of a 2:1 drug-DNA complex between distamycin A and an alternating B-DNA octamer duplex d(ICICICIC)2. The two distamycin A molecules are bound side by side with dyad symmetry in an antiparallel orientation in the expanded minor groove. The amides of each drug molecule are hydrogen bonded to the minor groove base atoms of only one DNA strand. The complex not only shows binding of two drug molecules, but the DNA duplex also exhibits striking low-high alternations in the helical twist angles, the sugar puckering and the phosphate conformations, providing the basis for a new model for an alternating B-DNA with a dinucleotide repeat.

About this Structure

159D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.

Reference

Binding of two distamycin A molecules in the minor groove of an alternating B-DNA duplex., Chen X, Ramakrishnan B, Rao ST, Sundaralingam M, Nat Struct Biol. 1994 Mar;1(3):169-75. PMID:7656035

Page seeded by OCA on Thu Mar 20 09:49:53 2008

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