2xr4

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[[Image:2xr4.png|left|200px]]
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==C-TERMINAL DOMAIN OF BC2L-C LECTIN FROM BURKHOLDERIA CENOCEPACIA==
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<StructureSection load='2xr4' size='340' side='right' caption='[[2xr4]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR4 OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene><br>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2wq4|2wq4]]</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xr4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xr4 RCSB], [http://www.ebi.ac.uk/pdbsum/2xr4 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Lectins and adhesins are involved in bacterial adhesion to host tissues and mucus during early steps of infection. We report the characterization of BC2L-C, a soluble lectin from the opportunistic pathogen Burkholderia cenocepacia, which has two distinct domains with unique specificities and biological activities. The N-terminal domain is a novel TNF-alpha-like fucose-binding lectin, while the C-terminal part is similar to a superfamily of calcium-dependent bacterial lectins. The C-terminal domain displays specificity for mannose and l-glycero-d-manno-heptose. BC2L-C is therefore a superlectin that binds independently to mannose/heptose glycoconjugates and fucosylated human histo-blood group epitopes. The apo form of the C-terminal domain crystallized as a dimer, and calcium and mannose could be docked in the binding site. The whole lectin is hexameric and the overall structure, determined by electron microscopy and small angle X-ray scattering, reveals a flexible arrangement of three mannose/heptose-specific dimers flanked by two fucose-specific TNF-alpha-like trimers. We propose that BC2L-C binds to the bacterial surface in a mannose/heptose-dependent manner via the C-terminal domain. The TNF-alpha-like domain triggers IL-8 production in cultured airway epithelial cells in a carbohydrate-independent manner, and is therefore proposed to play a role in the dysregulated proinflammatory response observed in B. cenocepacia lung infections. The unique architecture of this newly recognized superlectin correlates with multiple functions including bacterial cell cross-linking, adhesion to human epithelia, and stimulation of inflammation.
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Burkholderia cenocepacia BC2L-C Is a Super Lectin with Dual Specificity and Proinflammatory Activity.,Sulak O, Cioci G, Lameignere E, Balloy V, Round A, Gutsche I, Malinovska L, Chignard M, Kosma P, Aubert DF, Marolda CL, Valvano MA, Wimmerova M, Imberty A PLoS Pathog. 2011 Sep;7(9):e1002238. Epub 2011 Sep 1. PMID:21909279<ref>PMID:21909279</ref>
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The line below this paragraph, containing "STRUCTURE_2xr4", creates the "Structure Box" on the page.
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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{{STRUCTURE_2xr4| PDB=2xr4 | SCENE= }}
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===C-TERMINAL DOMAIN OF BC2L-C LECTIN FROM BURKHOLDERIA CENOCEPACIA===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21909279}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21909279 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21909279}}
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==About this Structure==
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[[2xr4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Burkholderia_cenocepacia Burkholderia cenocepacia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XR4 OCA].
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==Reference==
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<ref group="xtra">PMID:021909279</ref><references group="xtra"/>
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[[Category: Burkholderia cenocepacia]]
[[Category: Burkholderia cenocepacia]]
[[Category: Cioci, G.]]
[[Category: Cioci, G.]]

Revision as of 07:45, 14 May 2014

C-TERMINAL DOMAIN OF BC2L-C LECTIN FROM BURKHOLDERIA CENOCEPACIA

2xr4, resolution 1.90Å

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