2xh6

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[[Image:2xh6.png|left|200px]]
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==CLOSTRIDIUM PERFRINGENS ENTEROTOXIN==
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<StructureSection load='2xh6' size='340' side='right' caption='[[2xh6]], [[Resolution|resolution]] 2.69&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2xh6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH6 OCA]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene><br>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xh6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xh6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xh6 RCSB], [http://www.ebi.ac.uk/pdbsum/2xh6 PDBsum]</span></td></tr>
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<table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Clostridium perfringens enterotoxin (CPE) is a major cause of food poisoning and antibiotic-associated diarrhea. Upon its release from C. perfringens spores, CPE binds to its receptor, claudin, at the tight junctions between the epithelial cells of the gut wall and subsequently forms pores in the cell membranes. A number of different complexes between CPE and claudin have been observed, and the process of pore formation has not been fully elucidated. We have determined the three-dimensional structure of the soluble form of CPE in two crystal forms by X-ray crystallography, to a resolution of 2.7 and 4.0 A, respectively, and found that the N-terminal domain shows structural homology with the aerolysin-like beta-pore-forming family of proteins. We show that CPE forms a trimer in both crystal forms and that this trimer is likely to be biologically relevant but is not the active pore form. We use these data to discuss models of pore formation.
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Structure of the Food-Poisoning Clostridium perfringens Enterotoxin Reveals Similarity to the Aerolysin-Like Pore-Forming Toxins.,Briggs DC, Naylor CE, Smedley JG 3rd, Lukoyanova N, Robertson S, Moss DS, McClane BA, Basak AK J Mol Biol. 2011 Oct 14;413(1):138-49. Epub 2011 Aug 3. PMID:21839091<ref>PMID:21839091</ref>
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The line below this paragraph, containing "STRUCTURE_2xh6", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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{{STRUCTURE_2xh6| PDB=2xh6 | SCENE= }}
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===CLOSTRIDIUM PERFRINGENS ENTEROTOXIN===
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_21839091}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 21839091 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_21839091}}
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==About this Structure==
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[[2xh6]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XH6 OCA].
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==Reference==
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<ref group="xtra">PMID:021839091</ref><ref group="xtra">PMID:020606275</ref><references group="xtra"/>
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[[Category: Clostridium perfringens]]
[[Category: Clostridium perfringens]]
[[Category: Basak, A K.]]
[[Category: Basak, A K.]]

Revision as of 07:49, 14 May 2014

CLOSTRIDIUM PERFRINGENS ENTEROTOXIN

2xh6, resolution 2.69Å

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